Cui, Xinyuan; Chen, Xiaojun; Li, Yifu; Fu, Xiao; Song, Pan’ai; Xiao, Li; Sun, Lin; Liu, Hong; Zhu, Xuejing; Yuan, Shuguang published the artcile< Oxalate crystal-related acute renal injury caused by orlistat: A case report.>, Category: amides-buliding-blocks, the main research area is acute oxalic acid nephropathy; hyperoxaluria; orlistat.
We reported a case of oxalate crystal-related acute kidney injury caused by orlistat. The patient was admitted for nephrotic syndrome and acute kidney injury. The pathomorphological assessment of renal biopsy showed intratubular oxalate crystals. The patient reported that she had taken orlistat regularly to loss weight for more than a year. This patient had a habit of drinking vegetable soup and strong herbal tea daily. Orlistat, an intestinal lipase inhibitor, may cause secondary hyperoxaluria, that is, intestinal hyperoxaluria. Dietary habits could be a common precipitating factor for orlistat-relevant hyperoxaluria. It was comprehensively considered to be oxalate crystal-related acute renal injury, and the patient’s renal function recovered gradually after drug withdrawal. Clinicians should pay attention to screening drug-related acute kidney injury including orlistat when observing patients with unexplained acute kidney injury, and renal biopsy should be performed if necessary. It is also important to warn people who take the orlistat for weight loss about the side effects of this drug so as to adjust the eating habits.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Category: amides-buliding-blocks.
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