Asano, Toru; Yoshikawa, Tomohiro; Nakamura, Hiroyuki; Uehara, Yoshimasa; Yamamoto, Yoshinori published the artcile< Synthesis and biological evaluation of benzamides and benzamidines: structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinase>, HPLC of Formula: 5004-88-6, the main research area is benzamide benzamidine preparation epidermal growth factor receptor tyrosine kinase.
The benzamides I (R = cyclohexyl, 3-BrC6H4, 2-pyridyl, etc.) benzamidines II (R1 = 3-BrC6H4, 3-ClC6H4, 3-MeOC6H4, 3-chloro-4-fluorophenyl), and protected benzamidines (III, same R1) were synthesized as the mimics of 4-anilinoquinazolines, which possess inhibition of epidermal growth factor receptor (EGFR) tyrosine kinase, and were tested for cytotoxicity toward A431 and inhibitory activity toward autophosphorylation by the enzyme assay. High cell growth inhibition was observed in a series of the cyclic benzamides III: the IC50 values are 0.09-0.32 mM. The benzamidines III (R1 = 3-BrC6H4, 3-ClC6H4) exhibited high inhibition of EGFR tyrosine kinase at a 1.0 μM concentration, although the benzamides I and the benzamidines II did not show significant kinase inhibition at a 10 μM concentration
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, HPLC of Formula: 5004-88-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics