Althuis, T. H.; Moore, P. F.; Hess, H. J. published the artcile< Development of ethyl 3,4-dihydro-4-oxopyrimido[4,5-b]quinoline-2-carboxylate, a new prototype with oral antiallergy activity>, Formula: C9H12N2O3, the main research area is quinazolinecarboxylate analog preparation antiallergic; allergy inhibitor quinazolinecarboxylate analog; cromoglycate analog allergy inhibitor.
The synthesis and antiallergic activity is described of 18 3,4-dihydro-4-oxoquinazoline-2-carboxylic acid analogs I (R = H, MeO, NO2, Br, etc.; R1 = H or Et; X = CH or N) and II (R = H, CO2Na, CO2Et, OH, etc.; X = CH or N). The title compound II (R = CO2Et, X = N) [55149-04-7] was 10 times more potent (ED50 = 3 mg/kg, orally) than di-Na cromoglycate in the rat passive cutaneous anaphylaxis test. Structure-activity relations are discussed.
Journal of Medicinal Chemistry published new progress about Allergy. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Formula: C9H12N2O3.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics