Xia, Y.; Yang, Z.-Y.; Hour, M.-J.; Kuo, S.-C.; Xia, P.; Bastow, K. F.; Nakanishi, Y.; Nampoothiri, P.; Hackl, T.; Hamel, E.; Lee, K.-H. published the artcile< Antitumor Agents. Part 204:1 Synthesis and Biological Evaluation of Substituted 2-Aryl Quinazolinones>, Synthetic Route of 5004-88-6, the main research area is quinazolinone aryl preparation antitumor HIV agent; tubulin polymerization inhibitor arylquinazolinone preparation.
A series of 2-aryl-quinazolinones I (R6 = R7 = H, R2′ = F, R3′ = H, R4′ = H; R6 = R7 = H, R2′ = H, R3′ = F, R4′ = H; R6 = R7 = H, R2′ = H, R3′ = H, R4′ = F; R6 = R7 = OMe, R2′ = F, R3′ = H, R4′ = H; R6 = R7 = OMe, R2′ = H, R3′ = F, R4′ = H; R6 = R7 = OMe, R2′ = H, R3′ = H, R4′ = F; R6 = R7 = H, OMe, R2′ = H, R3’R4′ = CH:CHCH:CH; R6 = R7 = H, R2′ = H, R3′ = OMe, R4′ = H; R6 = OMe, R7 = H, R2′ = H, R3′ = OMe, R4′ = H; R6 = R7 = OMe, R2′ = H, R3′ = OMe, R4′ = H) was synthesized and evaluated for biol. activity. Among them, I (R6 = OMe, R7 = H, R2′ = H, R3′ = OMe) displayed significant growth inhibitory action against a panel of tumor cell lines and was also a potent inhibitor of tubulin polymerization Quinazolinones I (R6 = R7 = H, R2′ = F, R3′ = H, R4′ = H; R6 = R7 = H, R2′ = H, R3′ = F, R4′ = H; R6 = R7 = H, R2′ = H, R3′ = H, R4′ = F) displayed selective activity against P-gp-expressing epidermoid carcinoma of the nasopharynx. Anti-HIV activity of some of the prepared quinazolinones in acutely infected H9 lymphocytes was also assayed.
Bioorganic & Medicinal Chemistry Letters published new progress about Anti-HIV agents. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Synthetic Route of 5004-88-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics