Application In Synthesis of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamideOn May 10, 2012 ,《Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Worthington, Roberta J.; Bunders, Cynthia A.; Reed, Catherine S.; Melander, Christian. The article conveys some information:
The already considerable global public health threat of multidrug-resistant Gram-neg. bacteria has become even more of a concern following the emergence of New Delhi metallo-β-lactamase (NDM-1) producing strains of Klebsiella pneumoniae and other Gram-neg. bacteria. As an alternative approach to the traditional development of new bactericidal entities, we have identified a 2-aminoimidazole-derived small mol. that acts as an antibiotic adjuvant and is able to suppress resistance of a NDM-1 producing strain of K. pneumoniae to imipenem and meropenem, in addition to suppressing resistance of other β-lactam nonsusceptible K. pneumoniae strains. The small mol. is able to lower carbapenem min. inhibitory concentrations by up to 16-fold, while exhibiting little bactericidal activity itself. After reading the article, we found that the author used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Application In Synthesis of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Application In Synthesis of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics