Venkateswarlu, Somepalli; Satyanarayana, Meka; Lakshmikanthan, Vijaybaskar; Siddaiah, Vidavalur published the artcile< Fused Quinazolinoquinazolinones: Synthesis, Isomerization, Spectroscopic Identification, and Anticancer Activity>, Quality Control of 5004-88-6, the main research area is EGFR tyrosine kinase anticancer fused quinazolino quinazolinone; fused quinazolino quinazolinone preparation anticancer.
13H-quinazolino[3,4-a]quinazolin-13-ones have been synthesized from 2-aminobenzamides in four steps. An acid-catalyzed or base-catalyzed isomerization of 13H-quinazolino[3,4-a]quinazolin-13-ones to 8H-quinazolino[4,3-b]quinazolin-8-ones in excellent yields (90-95%) has been reported. The differences in the IR and NMR (1H & 13C) data of these isomeric fused quinazolinoquinazolinones afford a useful method for distinguishing between the two series. These analogs showed moderate anticancer activity (EGFR-TK inhibition).
Journal of Heterocyclic Chemistry published new progress about Epidermal growth factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Quality Control of 5004-88-6.
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