Suleiman, Joseph Bagi; Nna, Victor Udo; Zakaria, Zaida; Othman, Zaidatul Akmal; Bakar, Ainul Bahiyah Abu; Mohamed, Mahaneem published the artcile< Obesity-induced testicular oxidative stress, inflammation and apoptosis: Protective and therapeutic effects of orlistat>, HPLC of Formula: 96829-58-2, the main research area is orlistat antiobesity agent testicular oxidative stress inflammation apoptosis obesity; Apoptosis; High-fat diet; Inflammation; Obesity; Orlistat; Oxidative stress.
The objective of this study was to determine effects of the anti-obesity drug orlistat, on testicular oxidative stress, inflammation and apoptosis in high-fat diet (HFD)-fed rats. Twenty-four adult male Sprague Dawley rats weighing 250-300 g were randomized into four groups (n = 6/group), namely; normal control (NC), high-fat diet (HFD), HFD plus orlistat (10 mg/kg body weight/day administered concurrently for 12 wk) (HFD + Opr) and HFD plus orlistat (10 mg/kg body weight/day administered 6 wk after induction of obesity) (HFD + Ot) groups. Antioxidant enzymes activities were significantly decreased, while mRNA levels of pro-apoptotic markers (p53, Bax/BCl-2, caspase-9, caspase-8 and caspase-3) were significantly increased in the testis of HFD group relative to NC group. Furthermore, mRNA levels of pro-inflammatory markers (nuclear factor kappa B, inducible nitric oxide synthase, tumor necrosis factor alpha and interleukin (IL)-1beta increased significantly, while anti-inflammatory marker (IL-10) decreased significantly in testis of the HFD group relative to NC group. However, in both models of orlistat intervention (protective and treatment models) up-regulated antioxidant enzymes, down-regulated inflammation and apoptosis were observed in the testis of HFD-fed rats. Orlistat ameliorated testicular dysfunction by attenuating oxidative stress, inflammation and apoptosis in HFD-fed rats, suggesting its potential protective and therapeutic effects in the testis compromised by obesity.
Reproductive Toxicology published new progress about Anti-inflammatory agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, HPLC of Formula: 96829-58-2.
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