《Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy》 was published in Bioorganic & Medicinal Chemistry Letters in 2011. These research results belong to Sherer, Brian A.; Hull, Kenneth; Green, Oluyinka; Basarab, Gregory; Hauck, Sheila; Hill, Pamela; Loch, James T. III; Mullen, George; Bist, Shanta; Bryant, Joanna; Boriack-Sjodin, Ann; Read, Jon; DeGrace, Nancy; Uria-Nickelsen, Maria; Illingworth, Ruth N.; Eakin, Ann E.. Synthetic Route of C6H4Cl2N2O The article mentions the following:
The pyrrolamides are a new class of antibacterial agents targeting DNA gyrase, an essential enzyme across bacterial species and inhibition results in the disruption of DNA synthesis and subsequently, cell death. The optimization of biochem. activity and other drug-like properties through substitutions to the pyrrole, piperidine, and heterocycle portions of the mol. resulted in pyrrolamides with improved cellular activity and in vivo efficacy.2,6-Dichloroisonicotinamide(cas: 89281-13-0Synthetic Route of C6H4Cl2N2O) was used in this study.
2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C6H4Cl2N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics