Park, Yea-Jin; Seo, Dong-Wook; Ju, Jae-Yun; Cha, Yun-Yeop; An, Hyo-Jin published the artcile< The antiobesity effects of Buginawa in 3T3-L1 preadipocytes and in a mouse model of high-fat diet-induced obesity>, Electric Literature of 96829-58-2, the main research area is high fat diet obesity antiobesity bugi preadipocytes.
There has been a remarkable interest in finding lipid inhibitors from natural products to replace synthetic compounds, and a variety of oriental medicinal herbs are reported to have biol. activity with regard to lipid inhibition. Buginawa (Bugi) is a novel combined formula that contains twelve medicinal herbs with potential for weight loss induction. We hypothesized that Bugi may have antiobesity effects in 3T3-L1 preadipocytes and in a high-fat diet- (HFD-) induced mouse model. In this study, 3T3-L1 cells were treated with varied concentrations of Bugi (62.5, 125, or 250μg/mL). Bugi treatment inhibited adipocyte differentiation by suppressing adipogenic transcription genes, including peroxisome proliferator-activated receptor γ protein (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), sterol regulatory element-binding protein 1 (SREBP1), and CCAAT/enhancer-binding protein β (C/EBPβ).Mice were fed a normal diet or an HFD for 11 wk, and Bugi was simultaneously administered at 50 or 100mg/kg. Bugi administration significantly reduced body weight gain and white adipose tissue (WAT) weight and effectively inhibited lipid droplet accumulation in epididymal white adipose tissue (eWAT) and liver tissue. Further, Bugi treatment suppressed mRNA levels of PPARγ, C/EBPα, and SREBP1 in eWAT and liver tissue. Our findings demonstrate that Bugi could be an effective candidate for preventing obesity and relatedmetabolic disorders.
BioMed Research International published new progress about Adipocyte. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Electric Literature of 96829-58-2.
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