Formula: C11H22N2O4On March 31, 2021, Morgan, Charles W.; Dale, Ian L.; Thomas, Andrew P.; Hunt, James; Chin, Jason W. published an article in Journal of the American Chemical Society. The article was 《Selective CRAF Inhibition Elicits Transactivation》. The article mentions the following:
Discovering mols. that regulate closely related protein isoforms is challenging, and in many cases the consequences of isoform-specific pharmacol. regulation remains unknown. RAF isoforms are commonly mutated oncogenes that serve as effector kinases in MAP kinase signaling. BRAF/CRAF heterodimers are believed to be the primary RAF signaling species, and many RAF inhibitors lead to a “”paradoxical activation”” of RAF kinase activity through transactivation of the CRAF protomer; this leads to resistance mechanisms and secondary tumors. It has been hypothesized that CRAF-selective inhibition might bypass paradoxical activation, but no CRAF-selective inhibitor has been reported and the consequences of pharmacol. inhibiting CRAF have remained unknown. Here, we use bio-orthogonal ligand tethering (BOLT) to selectively target inhibitors to CRAF. Our results suggest that selective CRAF inhibition promotes paradoxical activation and exemplify how BOLT may be used to triage potential targets for drug discovery before any target-selective small mols. are known. In addition to this study using H-Lys(Boc)-OH, there are many other studies that have used H-Lys(Boc)-OH(cas: 2418-95-3Formula: C11H22N2O4) was used in this study.
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. Amino acids are not generally considered to be electrochemically active because products of the oxidation accumulate on the electrode surface and prevent it from participating in any further electrochemical processes.Formula: C11H22N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics