Mannucci, Edoardo; Monami, Matteo; Candido, Riccardo; Pintaudi, Basilio; Targher, Giovanni published the artcile< Effect of insulin secretagogues A meta-analysis of randomized controlled trials>, Application In Synthesis of 94-20-2, the main research area is meta analysis cardiovascular disease mortality insulin secretagogues; Insulin secretagogues; Major cardiovascular events; Metanalysis; Mortality; Type 2 diabetes.
Meta-anal. of insulin secretagogues (sulfonylureas and glinides) on major cardiovascular events and all-cause mortality. A MEDLINE database search was performed to identify all RCTs, up to Jan. 1st, 2020, with duration≥52 wk, in which insulin secretagogues (glibenclamide, gliclazide, glimepiride, glipizide, chlorpropamide, repaglinide, nateglinide) were compared with either placebo or active comparators. The principal endpoints were MACE (restricted for RCT reporting MACEs within their outcomes) and all-cause mortality (irresp. of the inclusion of MACEs among the pre-specified outcomes). Mantel-Haenszel odds ratio (MH-OR) with 95% Confidence Interval (95% CI) was calculated for all the endpoints considered. Fourteen RCTs were included in the anal. for MACEs (919 in insulin secretagogues and 1,087 in control group). Insulin secretagogues were not significantly associated with an increased risk of MACEs in comparison with controls (MH-OR 1.08 [95% CI 0.96, 1.22], p = 0.20). When considering the 48 RCTs fulfilling criteria for inclusion in the anal. on all-cause mortality, insulin secretagogues were associated with a significantly increased risk of all-cause mortality (MH-OR 1.11 [1.00, 1.23], p = 0.04).This meta-anal. suggests that insulin secretagogues are associated with an increased risk of all-cause mortality when compared with placebo or other anti-hyperglycemic drugs.
Nutrition, Metabolism & Cardiovascular Diseases published new progress about Cardiovascular disease. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Application In Synthesis of 94-20-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics