Lin, Kai-Huang; Luo, Ci-Wen; Chen, Shih-Pin; Tu, Dom-Gene; Lin, Ming-Shian; Kuan, Yu-Hsiang published the artcile< Inhibitor of α-glucosidase can effectively inhibit therisk of tuberculosis in patients with diabetes: a nestedcase-control study>, Computed Properties of 94-20-2, the main research area is alpha glucosidase inhibitor antituberculosis antidiabetic agent tuberculosis diabetes.
Diabetes mellitus (DM) and tuberculosis (TB) are major public health and economic burdens. DM increases Mycobacterium tuberculosis infection rates and treatment durations. This study evaluated the relationship between five classes of oral DM medications and TB infection risk in DM patients. We used longitudinal records from the Taiwan Longitudinal Health Insurance Research Database. DM patients were identified using the International Classification of Diseases. TB patients were identified. Oral DM medications were divided into five classes: sulfonylureas, biguanides, meglitinides, α-glucosidase inhibitors (AGIs), and thiazolidinediones. Users were classified as nonusers, low-concentration users, and high-concentration users. The incidence rate ratio (IRR) was derived using multivariate Poisson regression to calculate the relative risk of TB infection. DM patients using low- and high-concentration AGIs had significantly lower TB infection risks compared with nonusers. The IRRs of the sulfonylureas and AGI users were (CI 0.693-0.948) and (95% CI 0.651-0.995), resp. The other four classes of medications exhibited no significant effect on TB infection risk in DM patients. Furthermore, DM patients using highconcn. AGIs had a significantly lower TB infection risk compared with those using low-concentration AGIs (IRR 0.918, 95% CI: 0.854-0.987). We noted a dose-response relationship in the effects of DM medications on TB risk. Accordingly, we suggest that DM patients use AGIs to benefit from their protective effect on TB infection risk.
BioMed Research International published new progress about Antidiabetic agents. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Computed Properties of 94-20-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics