Knoke, Sabrina; Bunjes, Heike published the artcile< Transfer investigations of lipophilic drugs from lipid nanoemulsions to lipophilic acceptors: contributing effects of cholesteryl esters and albumin as acceptor structures>, Safety of (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate, the main research area is lipophilic drug acceptor lipid nanoemulsion cholesteryl ester albumin; bovine serum albumin; cholesteryl nonanoate; colloidal drug carriers; drug transfer; hydrogel beads; in vitro release; lipid nanoparticles.
When studying the release of poorly water-soluble drugs from colloidal drug delivery systems designed for i.v. administration, the release media should preferentially contain lipophilic components that represent the physiol. acceptors present in vivo. In this study, the effect of different acceptor structures was investigated by comparing the transfer of fenofibrate, retinyl acetate, and orlistat from trimyristin nanoemulsion droplets into lipid-containing hydrogel particles, as well as to bovine serum albumin (BSA). A nanodispersion based on trimyristin and cholesteryl nonanoate was incorporated into the hydrogel particles (mean diameter ~40μm) in order to mimic the composition of lipoproteins. The course of transfer observed utilizing the lipid-containing hydrogel particles as an acceptor was in relation to the lipophilicity of the drugs: the higher the logP value, the slower the transfer. There was no detectable amount of the drugs transferred to BSA in liquid solution, demonstrating clearly that albumin alone does not contribute substantially as acceptor for the lipophilic drugs under investigation in this study. In contrast, cholesteryl nonanoate contributes to a much greater extent. However, in all cases, the partition equilibrium of the drugs under investigation was in favor of the trimyristin emulsion droplets.
Pharmaceuticals published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Safety of (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics