《3D Printed High-Throughput Hydrothermal Reactionware for Discovery, Optimization, and Scale-Up》 was published in Angewandte Chemie, International Edition in 2014. These research results belong to Kitson, Philip J.; Marshall, Ross J.; Long, Deliang; Forgan, Ross S.; Cronin, Leroy. Quality Control of N-(Pyridin-4-yl)isonicotinamide The article mentions the following:
3D printing techniques allow the laboratory-scale design and production of reactionware tailored to specific exptl. requirements. To increase the range and versatility of reactionware devices, sealed, monolithic reactors suitable for use in hydrothermal synthesis were digitally designed and realized. The fabrication process allows the introduction of reaction mixtures directly into the reactors during the production, and also enables the manufacture of devices of varying scales and geometries unavailable in traditional equipment. The utility of these devices is shown by the use of 3D printed, high-throughput array reactors to discover two new coordination polymers, optimize the synthesis of one of these, and scale-up its synthesis using larger reactors produced on the same 3D printer. Reactors were also used to produce phase-pure samples of coordination polymers MIL-96 and HKUST-1, in yields comparable to synthesis in traditional apparatusN-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Quality Control of N-(Pyridin-4-yl)isonicotinamide) was used in this study.
N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Quality Control of N-(Pyridin-4-yl)isonicotinamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics