Hattori, Tomohiro; Yamamoto, Hisashi published an article on February 2 ,2022. The article was titled 《Synthesis of silacyclic dipeptides: Peptide elongation at both N- and C-termini of dipeptide》, and you may find the article in Journal of the American Chemical Society.Synthetic Route of C11H22N2O4 The information in the text is summarized as follows:
A new type of peptide bond formation utilizing silacyclic amino acids or peptides is described. This work has the following advantages: (1) imidazolylsilane is a highly fascinating coupling reagent for dipeptide synthesis from N-,C-terminal unprotected amino acids with amino acid tert-Bu esters; (2) deprotection of the tert-Bu ester at the C-terminus and cyclization sequentially proceed depending on reaction conditions to afford novel silacyclic dipeptides; (3) the cyclized products show a remarkable capacity as substrates of peptide elongation because the silacyclic compounds can act as both nucleophiles and electrophiles, and this capacity lead to one-pot site-selective tetra- and oligopeptide syntheses. These innovative advantages will help to simplify classical peptide synthesis significantly. In the experimental materials used by the author, we found H-Lys(Boc)-OH(cas: 2418-95-3Synthetic Route of C11H22N2O4)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Synthetic Route of C11H22N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics