《Continuous process improvement in the manufacture of carfilzomib. Part 1: Process understanding and improvements in the commercial route to prepare the epoxyketone warhead》 was written by Dornan, Peter K.; Anthoine, Travis; Beaver, Matthew G.; Cheng, Guilong Charles; Cohen, Dawn E.; Cui, Sheng; Lake, William E.; Langille, Neil F.; Lucas, Susan P.; Patel, Jenil; Powazinik, William; Roberts, Scott W.; Scardino, Chris; Tucker, John L.; Spada, Simone; Zeng, Alicia; Walker, Shawn D.. Formula: C13H26N2O4 And the article was included in Organic Process Research & Development on April 17 ,2020. The article conveys some information:
In the first case study, the mechanism of racemization of an α-chiral enone was investigated, resulting in the development of an improved aqueous workup procedure. Next, the stability of a bleach/pyridine mixture used for the step 3 epoxidation reaction was studied, leading to the identification of pyridine as a key raw material and improved reaction conditions and control strategy to meet the conversion target. Finally, oxidized butylated hydroxytoluene (oBHT) was identified as an impurity arising from the use of BHT-stabilized THF in steps preceding the oxidation The process understanding obtained from these investigations have led to the implementation of process improvements which improve the robustness of the process. The development of a second-generation route to epoxyketone I was the subject of the second manuscript in this series. After reading the article, we found that the author used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Formula: C13H26N2O4)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Formula: C13H26N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics