《Expedient Pd-Catalyzed α-Arylation towards Dibenzoxepinones: Pivotal Manske’s Ketone for the Formal Synthesis of Cularine Alkaloids》 was written by Deichert, Julie A.; Mizufune, Hideya; Patel, Jignesh J.; Hurst, Timothy E.; Maheta, Ashish; Kitching, Mathew O.; Ross, Avena C.; Snieckus, Victor. Category: amides-buliding-blocks And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:
The general synthesis of diversely substituted dibenzoxepinones by a combined Pd-catalyzed α-arylation and SNAr strategy is reported and applied to the synthesis of Manske’s ketone, a key intermediate en route to the total synthesis of cularine alkaloids. In the course of this work, an unanticipated ring contraction reaction to a xanthone was observed and serves as a caveat for the conditions of the widely used α-arylation reaction. Thus, e.g., o-(2-bromophenoxy)acetophenone → dibenzoxepinone I (72%) in presence of Pd2(dba)3 and XantPhos, Cs2CO3 as base and toluene as solvent. The results came from multiple reactions, including the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Category: amides-buliding-blocks)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics