HPLC of Formula: 87694-50-6On May 5, 1998 ,《The design and synthesis of inhibitors of the cysteinyl protease, Der p I》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Billson, Jeremy; Clark, Jonathan; Conway, Simon P.; Hart, Terance; Johnson, Tony; Langston, Steven P.; Ramjee, Manoj; Quibell, Martin; Scott, Richard K.. The article conveys some information:
Prototype irreversible inhibitors I [R = H, Me3CO2C (Boc), Ac, Bz, R1 = CO2Et; R = Boc, R1 = SO2Me, SO2CH2Ph, SO2Ph] and II (R2 = H, Me, Cl, CF3) of the cysteinyl protease Der p I were designed, synthesized and evaluated in vitro. Candidates were designed using a modular approach, whereby a peptide sequence was appended with known thiophilic moieties. This hinged on utilizing peptide sequences from substrate specificity data compiled using proprietary RAPiD technol. The experimental process involved the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6HPLC of Formula: 87694-50-6)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.HPLC of Formula: 87694-50-6 In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics