B, Haripriya; Hasija, Avantika; Cruz-Cabeza, Aurora J.; Shruti, Ipsha; Chopra, Deepak published the artcile< Multicomponent Crystals of Chlorpropamide: Multiple Conformers, Multiple Z', and Proton Transfer at Play>, HPLC of Formula: 94-20-2, the main research area is multicomponent crystal chlorpropamide multiple conformer crystallog.
A new organic salt and a cocrystal of the antidiabetic drug chlorpropamide (cpa) were obtained by mechanochem. liquid-assisted grinding (LAG) with several cocrystal formers. An organic salt was formed with 4-(dimethylamino)pyridine (cpa:DMAP) and a cocrystal was obtained with 4,4′-dipyridyl (cpa:BP). After extensive screening for polymorphism/stoichiomorphism, two polymorphs of the cpa:DMAP salt (Forms I and II) and one form of the cocrystal cpa:BP were discovered. cpa:DMAP-I crystallized with eight mols. in the asym. unit (Z’ = 4, Z” = 8), whereas cpa:DMAP-II crystallized with two mols. in the asym. unit (Z’ = 1, Z” = 2). The new forms were characterized via single-crystal X-ray diffraction and powder X-ray diffraction along with thermal methods of characterization. Addnl., the various conformers found in these multicomponent forms are analyzed and compared to the known polymorphs of cpa. Finally, we show that the stable polymorph of the salt cpa:DMAP-I has a drastically enhanced aqueous solubility and dissolution rate relative to the pure cpa, thus giving it an advantage for improved drug delivery.
Crystal Growth & Design published new progress about Cocrystallization. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, HPLC of Formula: 94-20-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics