Ahmad, Tanveer; Mehmood, Tariq; Shahid, Muhammad; Ahmad, Adnan; Basra, Muhammad Asim Raza; Zia-ur-Rehman, Muhammad; Munawar, Munawar Ali published the artcile< In vivo anti-diabetic studies of sulfonylurea-sulfonamide hybrids>, HPLC of Formula: 94-20-2, the main research area is antidiabetic sulfonylurea sulfonamide hybrid.
Owing to alarming increase of diabetes mellitus around the world, there is a need to discover new mols. to tackle with the problem. In this work, sulfonamides and sulfonylurea-sulfonamide hybrids were synthesized from simple mol. of 4-aminobenzenesulfonamide by its reaction with aryl sulfonyl chlorides. Anti-diabetic activities of these pharmacophores were studied by oral glucose tolerance test (OGTT) percentage anal. on Sprague Dawley (SD) rats at the dose of 20mg/kg using glibenclamide (GC). Among these synthesized pharmacophores, six compounds exhibited percentage reduction (20.47 ± 2.54 to 44.97 ± 2.16%) and (20.79 ± 1.55 to 37 ± 2.94%) in blood glucose level at 20mg/kg dose compared to glibenclamide (74 ± 3.10% reduction) 50mg/kg dose of glibenclamide after 2 and 5 h of oral administration resp. Present results showed that these compounds might be excellent addition in the drugs used to suppress the higher level of blood glucose level in diabetes mellitus.
Pakistan Journal of Zoology published new progress about Antidiabetic agents. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, HPLC of Formula: 94-20-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics