Vasconcelos, Ingrid; da Silva, Pedro Henrique Reis; Dias, Derick Rodrigues Davila; de Freitas Marques, Maria Betania; da Nova Mussel, Wagner; Pedrosa, Tercio Assuncao; Ribeiro e Silva, Maria Elisa Scarpelli; de Souza Freitas, Roberto Fernando; de Sousa, Ricardo Geraldo; Fernandes, Christian published the artcile< Synthesis and characterization of a molecularly imprinted polymer (MIP) for solid-phase extraction of the antidiabetic gliclazide from human plasma>, Computed Properties of 94-20-2, the main research area is gliclazide molecularly imprinted polymer solid phase extraction; Diabetes mellitus; Molecularly imprinted solid-phase extraction; Sample preparation; Sulfonylureas.
Gliclazide is a sulfonylurea frequently prescribed for the management of type 2 diabetes mellitus in elderly patients and for patients with chronic renal or hepatic diseases. Even though it is considered a safer alternative, the drug can provoke side effects in some patients, especially hypoglycemia, due to the high interindividual variability. Therefore, the quantification of gliclazide in biol. samples is usually recommended in order to assure efficacy and safety of the pharmacotherapy. However, due to the complexity of biol. matrixes, therapeutic monitoring can be very challenging, especially in the sample preparation step. Synthesis conditions were optimized (monomer, crosslinker and porogen) and the polymer was characterized for its morphol., physicochem. and stability properties. The influence of drug concentration, solvent composition and pH on the coefficient of distribution (Kd) and imprinting factor (IF) were studied, as well as repeatability between batches and selectivity. The best reaction yield, extraction capacity, and selectivity was obtained using 2-hydroxyethyl methacrylate (2-HEMA), ethyleneglycol dimethacrylate (EGDMA) and acetonitrile. The developed method by MISPE-HPLC-UV showed to be appropriate to determine gliclazide in human plasma samples.
Materials Science & Engineering, C: Materials for Biological Applications published new progress about Blood plasma. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Computed Properties of 94-20-2.
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