Uebler, Jacob W.; LaDuca, Robert L. published an article in Acta Crystallographica, Section E: Structure Reports Online. The title of the article was 《Diaquabis[N-(pyridin-4-yl)isonicotinamide-κN]bis(thiocyanato-κN)cobalt(II)》.Synthetic Route of C11H9N3O The author mentioned the following in the article:
In the title compound, [Co(NCS)2(C11H9N3O)2(H2O)2], the octahedrally coordinated CoII ion lies on a crystallog. inversion center and is bound by two isothiocyanate ligands, two aqua ligands and two N-(pyridin-4-yl)isonicotinamide (4-pina) ligands. The dihedral angle between the aromatic rings in the 4-pina ligand is 8.98(11)°. In the crystal, the individual mol. units are aggregated in three dimensions by O-H···N, O-H···S, and N-H···S hydrogen bonds. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Synthetic Route of C11H9N3O)
N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Synthetic Route of C11H9N3O The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics