In 2016,Trabbic, Christopher J.; George, Sage M.; Alexander, Evan M.; Du, Shengnan; Offenbacher, Jennifer M.; Crissman, Emily J.; Overmeyer, Jean H.; Maltese, William A.; Erhardt, Paul W. published 《Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: effects on potency and mode of activity》.European Journal of Medicinal Chemistry published the findings.Recommanded Product: 78191-00-1 The information in the text is summarized as follows:
A series of [(pyridinylcarbonyl)vinyl]indoles I [R1 = 4-MeO, 6-MeO, 7-MeO, 5,6-(MeO)2, R2 = H, R3 = Me; R1 = 6-MeO, R2 = H, R3 = CF3; R1 = 5-MeO, R2 = R3 = Me; R4 = 4-pyridinyl] as well as their aroylvinyl analogs I [R1 = 5-MeO; R2 = H; R3 = Me; R4 = 2,4,6-(MeO)3C6H2, 3,4,5-(MeO)3C6H2] with methoxy groups on the indole ring have been synthesized and evaluated for anticancer activity. The location of the methoxy group was shown to alter both the potency and mechanism of cell death. Remarkably, changing the methoxy from the 5-position to the 6-position switched the biol. activity from induction of methuosis to disruption of microtubules. The latter may represent a prototype for a new class of mitotic inhibitors with potential therapeutic utility. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1) was used in this study.
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 78191-00-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics