Synthetic Route of C7H9NO2SIn 2020 ,《Au(I)/Au(III)-Catalyzed C-N coupling》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Rodriguez, Jessica; Adet, Nicolas; Saffon-Merceron, Nathalie; Bourissou, Didier. The article conveys some information:
Cycling between Au(I) and Au(III) is challenging, so gold-catalyzed cross-couplings are rare. The (MeDalphos)AuCl complex, which the authors showed was prone to undergo oxidative addition, is reported here to efficiently catalyze the C-N coupling of aryl iodides and amines. The transformation does not require an external oxidant or a directing group. It is robust and works with a wide scope of aryl iodides and N-nucleophiles under mild conditions. Mechanistic studies, including the NMR and MS characterization of a key aryl amido Au(III) complex, strongly support a 2e redox cycle in which oxidative addition precedes transmetalation and reductive elimination is the rate-determining step.4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S) was used in this study.
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C7H9NO2S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics