Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamideOn March 31, 1984, Polivka, Zdenek; Holubek, Jiri; Svatek, Emil; Metys, Jan; Protiva, Miroslav published an article in Collection of Czechoslovak Chemical Communications. The article was 《Potential hypnotics and anxiolytics: synthesis of 2-bromo-4-(2-chlorophenyl)-9-[4-(2-methoxyethyl)piperazino]-6H-thieno[3,2-f]-1,2,4-triazolo[4,3-a]-1,4-diazepine and of some related compounds》. The article mentions the following:
Title compounds I (R = MeO, EtO, MeS, n = 2; R = MeO, n = 3) were prepared by alkylation of thienotriazolodiazepine II (R1 = R2 = Br) with substituted piperazines. I (R = PhO, PhS, n = 2) were prepared by alkylation of I (R1 = piperazino, R2 = Br). Cyclization of hydrazinothienodiazepine III with ClC(OEt)3 gave II (R1 = R2 = H), which could only be brominated to give I (R1 = Br, R2 = H). Some intermediates were prepared for the synthesis etizolam. I had less anticonvulsant activity than 8-chloro-6-(2-chlorophenyl)-1-piperazino-4H-s-triazolo[4,3-a]-1,4-benzodiazepines. The results came from multiple reactions, including the reaction of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide)
2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics