Nakamura, Akio; Yamada, Tetsuhiro; Asaki, Tetsuo published the artcile< Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist>, Electric Literature of 25999-04-6, the main research area is diphenyl pyrazine sulfonamide prodrug preparation hydrolysis.
N-Acylsulfonamide and N-acylsulfonylurea derivatives of the carboxylic acid prostacyclin receptor agonist 1 (I) were synthesized and their potential as prodrug forms of the carboxylic acid was evaluated in vitro and in vivo. These compounds were converted to the active compound 1 by hepatic microsomes from rats, dogs, monkeys, and humans, and some of the compounds were shown to yield sustained plasma concentrations of 1 when they were orally administered to monkeys. These types of analogs, including NS-304 (2a), are potentially useful prodrugs of 1.
Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Electric Literature of 25999-04-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics