Liu, Xing-Ping; Narla, Rama Krishna; Uckun, Fatih M. published the artcile< Organic phenyl arsonic acid compounds with potent antileukemic activity>, Product Details of C9H12N2O3, the main research area is phenyl arsonic acid quinazoline preparation potent antileukemic activity; chlorodimethoxyquinazoline condensation reaction aminophenylazo phenylarsonic acid.
12 Organic arsonic acid compounds, e.g. I, were synthesized and evaluated against human B-lineage (NALM-6) and T-lineage (MOLT-3) acute lymphoblastic leukemia (ALL) cell lines. E.g., I was prepared from condensation of 4-chloro-6,7-dimethoxyquinazoline and 4-(4′-aminophenylazo)phenylarsonic acid. The lead compounds 2-trichloromethyl-4-[4′-(4”-phenylazo)phenylarsonic acid]aminoquinazoline (compound 19, PHI-P518; IC50=1.1 ± 0.5 μM against NALM-6 and 2.0 ± 0.8 μM against MOLT-3) and 2-methylthio-4-(2′-phenylarsonic acid)aminopyrimidine (compound 15, PHI-P381; IC50=1.5 ± 0.3 μM against NALM-6 and 2.3 ± 0.5 μM against MOLT-3) exhibited potent antileukemic activity at low micromolar concentrations
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Product Details of C9H12N2O3.
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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics