Reference of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamideOn May 31, 1994, Kaljuste, Kalle; Unden, Anders published an article in International Journal of Peptide & Protein Research. The article was 《A new general solid-phase method for the synthesis of backbone-to-backbone cyclized peptides》. The article mentions the following:
A model peptide with the sequences Ala-Pro-Lys(2ClZ)-Tyr(2BrZ) was synthesized on a 4-methylbenzhydryl amine (MBHA) polystyrene resin using conventional Boc/benzyl protective group strategy. The amino acid aldehyde Boc-valinal was coupled by reductive alkylation with NaCNBH3 in acidified DMF for 1 h. The secondary amine in the peptide-resin Boc-Valψ[CH2NH]Ala-Pro-Lys(2ClZ)-Tyr(2BrZ)-MBHA was reductively alkylated by 3(4-methylbenzylthio)propanal at 40° for 6 h, resulting the peptide-resin Boc-Valψ[CH2N(CH2CH2CH2S-pMeBzl)]Ala-Pro-Lys(2ClZ)-Tyr(2BrZ)-MBHA. After the removal of the Boc group the synthesis was continued employing the above-mentioned methods, which led to the resin-bound peptide Leuψ[CH2N(CH2CH2CH2S-pMeBzl)]Ser-Pro-Gly-Lys(2ClZ)-Valψ[CH2N(CH2CH2CH2S-pMeBzl)]Ala-Pro-Lys(2ClZ)-Tyr(2BrZ)-MBHA. The peptide was cleaved from the resin with hydrogen fluoride. Reversed-phase HPLC and plasma desorption mass spectrometry anal. showed that the expected peptide Leuψ[CH2N(CH2CH2CH2SH)]Ser-Pro-Gly-Lys-Valψ[CH2N(CH2CH2CH2SH)]Ala-Pro-Lys-Tyr-NH2 was obtained as the major product with low levels of side products. Intramol. oxidation of the thiols gave the backbone to backbone cyclized peptide I. In the experiment, the researchers used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Reference of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Reference of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics