In 2022,de Jesus Cruz, Pedro; Cassels, William R.; Chen, Chun-Hsing; Johnson, Jeffrey S. published an article in Science (Washington, DC, United States). The title of the article was 《Doubly stereoconvergent crystallization enabled by asymmetric catalysis》.Synthetic Route of C4H9NO2 The author mentioned the following in the article:
Herein, discovery and development of a catalyst-mediated asym. Michael addition/crystallization-induced diastereomer transformation of broad scope was reported. The sequence controlled three stereogenic centers, two of which were stereochem. labile. The configurational instability of 1,3-dicarbonyls and nitroalkanes, typically considered a liability in stereoselective synthesis, was productively leveraged by merging enantioselective Bronsted base organocatalysis and thermodn. stereocontrol using a single convergent crystallization The synthesis of useful γ-nitro β-keto amides containing three contiguous stereogenic centers was thus achieved from Michael acceptors containing two prochiral centers. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C4H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics