《Synthesis of novel pyridine and pyrimidine derivatives as potential inhibitors of HIV-1 reverse transcriptase using palladium-catalysed C-N cross-coupling and nucleophilic aromatic substitution reactions》 was published in ARKIVOC (Gainesville, FL, United States) in 2020. These research results belong to Changunda, Charles R. K.; Rousseau, Amanda L.; Basson, Adriaan E.; Bode, Moira L.. Electric Literature of C6H4Cl2N2O The article mentions the following:
Palladium-mediated cross-coupling reactions are used in the successful construction of a small library of flexible heteroatom-linked diarylpyridine target compounds I (R = H, cyano, cyclopropylamino; R1 = cyano, aminocarbonyl, cyclopropylamino; R2 = 4-chlorophenoxy, 2-cyano-5-methylphenyl, cyclohexylamino), including pyridines bearing a secondary amide substituent. Heteroatom-linked diarylpyrimidine derivatives II (R3 = 4-Cl, 2,4-Cl2, 3,5-Cl2, 4-F, 3-CF3; R4 = 5-methylpyridin-2-yl, 5-chloropyrimidin-2-yl, 2-cyano-5-methylphenyl) bearing a chlorine substituent are prepared by base-catalyzed nucleophilic aromatic substitution reactions without the need for palladium catalysis.2,6-Dichloroisonicotinamide(cas: 89281-13-0Electric Literature of C6H4Cl2N2O) was used in this study.
2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Electric Literature of C6H4Cl2N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics