Application In Synthesis of 2-BromoacetamideIn 2019 ,《Solid-phase synthesis of a novel phalloidin analog with on-bead and off-bead actin-binding activity》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Blanc, Antoine; Todorovic, Mihajlo; Perrin, David M.. The article contains the following contents:
Specific effectors of actin polymerization have found use as dynamic probes of cellular morphol. that may be used to gauge cellular response to stimuli and drugs. Of various natural products that target actin, phalloidin is one of the most potent and selective inhibitors of actin depolymerization Phalloidin and related members of the phallotoxin family are macrocyclic heptapeptides bearing a characteristic and rigidifying transannular tryptathionine bridge. Here we describe a solid-phase synthesis of a new phalloidin analog as a prototype for library development with the potential for on- and off-bead screening. To validate our method, we labeled the phalloidin derivative with a fluorescent dye which stained actin in CHO cells. Furthermore, a bioassay was developed allowing actin polymerization on beads carrying a phalloidin derivative In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Application In Synthesis of 2-Bromoacetamide)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application In Synthesis of 2-Bromoacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics