Zheng, Ye; Martinez-Acosta, Jaime A.; Khimji, Mohammed; Barbosa, Luiz C. A.; Clarkson, Guy J.; Wills., Martin published the artcile< Asymmetric Transfer Hydrogenation of Aryl Heteroaryl Ketones using Noyori-Ikariya Catalysts>, Computed Properties of 1192620-83-9, the main research area is aryl heteroaryl alc preparation enantioselective; heteroaryl aryl ketone asym transfer hydrogenation Noyori Ikariya catalyst.
A range of ketones ArC(O)R (Ar = Ph, 2-bromophenyl, naphthalen-1-yl, etc.; R = furan-2-yl, thiophen-2-yl, 1-methyl-1H-imidazol-2-yl) flanked by a combination of an aromatic and a heterocyclic ring were reduced under asym. transfer hydrogenation (ATH) conditions. Using a range of [(arene)Ru(TsDPEN)Cl] precatalysts, including tethered derivatives, I, the reduction enantioselectivity was high (up to 99% ee) in cases where the aromatic ring contained an ortho-substituent. The enantioselectivity is influenced by a combination of steric and electronic factors which for the furan and thiophene series, follow literature precedents. In the case of the N-methylimidazole-containing ketones ArC(O)R (R = 1-methyl-1H-imidazol-2-yl), an unexpected switch in enantioselectivity took place upon variation of the opposing aromatic group. Pyrrole- containing ketones II (R1 = Me, tert-butoxycarbonyl) were resistant to reduction This study demonstrates the asym. transfer hydrogenation (ATH) of a range of hindered heterocyclic ketones, in high conversion and ee, using Noyori-Ikariya catalysts I.
ChemCatChem published new progress about Aromatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Computed Properties of 1192620-83-9.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics