Yousef, Farah; Mansour, Oussama; Herbali, Jehad published the artcile< Rigid docking application to investigate sulfonylurea family members' binding site with their receptor KIR6.2SUR1>, Electric Literature of 94-20-2, the main research area is sulfonylurea glibenclamide chlorpropamide antihyperglycemic agent KIR62 SUR1 mol docking.
Sulfonylurea family members have been used as a second preferred line in the treatment of Type II Diabetes Mellitus (TIIDM) for decades. Only one crystal structure for its receptor Kir6.2SUR1 binding with one of sulfonylurea member; Glibenclamide (GBM), is available in Protein Data Bank (PDB) database. The aim of this manuscript is to study in-silico other sulfonylurea family members’ interactions with their receptor Kir6.2SUR1 using a docking software in the default settings. We have checked the validity of the software for the study. Then, rigid docking had been applied on 14 compounds of sulfonylurea group which they have anti-hyperglycemia activity. Next, we have compared their interactions to GBM interactions with Kir6.2SUR1. As a result, many compounds of this family had bound to Kir6.2SUR1 receptor in the same pocket as GBM. These results confirmed a perspective we have discussed about sulfonylurea structure activity relationship.
International Journal of Pharma and Bio Sciences published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Electric Literature of 94-20-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics