Yamaguchi, Hachiro; Tsujihara, Kenji published the artcile< Sulfonyl diamide derivatives. II. Amide exchange reaction of sulfonyl diamide>, Application In Synthesis of 25999-04-6, the main research area is exchange amine sulfonyl diamide.
In the amide exchange reaction of sulfonyl diamide with amines, the reaction with primary amines under anhydrous conditions gave monosubstituted products at first and then N,N’-disubstituted products. However, the reaction with primary amines under aqueous conditions and with secondary amines in the absence of water gave only mono substituted products. The first intermediates were N-monosubstituted sulfonyl diamides in the case of primary amines, and N,N’-disubstituted sulfonyl diamides in the case of secondary amines. 1,3-Disubstituted imidodisulfonyl diamide was isolated as an intermediate from the reaction under anhydrous conditions, and 1-monosubstituted imidodisulfonyl diamide was isolated as an intermediate from the reaction under aqueous conditions. The former reacted with anhydrous primary amine to give N,N’-disubstituted sulfonyl diamide. The latter reacted with aqueous primary amine to give N-monosubstituted sulfonyl diamide.
Nippon Kagaku Kaishi published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Application In Synthesis of 25999-04-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics