Yamaguchi, Hachiro; Nakano, Keiji published the artcile< Hydrolysis of N-substituted derivatives of sulfamide>, Application of C4H10N2O3S, the main research area is sulfamic acid sulfamide hydrolysis; sulfamide alkyl benzyl hydrolysis; alkylsulfamide hydrolysis kinetics; benzylsulfamide hydrolysis kinetics; hydrolysis sulfamide derivative kinetics.
N-Alkyl- or -benzylsulfamides were hydrolyzed to the corresponding N-substituted sulfamates (RNHSO3NH4) in ∼ 44-87% yield with H2O and to H2NSO3Na in ∼ 64-95% yield with aqueous NaOH. N,N-Disubstituted sulfamides containing a heterocyclic ring were hydrolyzed mainly to sulfamates with H2O or NaOH. sym-N,N’-Dialkyl- or -benzylsulfamides were converted into N-substituted sulfamates in 50-97% yield with NaOH and into N,N’-disubstituted sulfamates in 63-93% yield with H2O, but (Et2N)2SO2 was hydrolyzed only with difficulty by H2O or NaOH. The reaction mechanisms were explained through electron density and steric complexity.
Hiroshima Daigaku Kogakubu Kenkyu Hokoku published new progress about Hydrolysis kinetics. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Application of C4H10N2O3S.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics