Simons, R. Thomas; Scott, Georgia E.; Kanegusuku, Anastasia Gant; Roizen, Jennifer L. published the artcile< Photochemically Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides>, Name: Morpholine-4-sulfonamide, the main research area is photocatalyst nickel heteroaryl sulfamide arylbromide arylation.
A general method for the N-arylation of sulfamides with aryl bromides is described. The protocol leverages a dual-catalytic system, with [Ir(ppy)2(dtbbpy)]PF6 as a photosensitizer, NiBr2•glyme as a precatalyst, and DBU as a base, and proceeds at room temperature under visible light irradiation Using these tactics, aryl boronic esters and aryl chlorides can be carried through the reaction untouched. The developed reactions efficiently engage simple bromoarenes and primary sulfamides in between 66% and quant. yields. For more challenging substrates, such as secondary sulfamides, reaction efficiency is documented. Thereby, these methods complement known Buchwald-Hartwig coupling methods for N-arylation of sulfamides. A general method for the N-arylation of sulfamides with aryl bromides is described. The protocol leverages a dual-catalytic system of Ni and a photoexcitable Ir complex and proceeds at room temperature under visible light irradiation Using these tactics, aryl boronic esters and aryl chlorides can be carried through the reaction untouched. Thereby, this method complements known Buchwald-Hartwig coupling methods for N-arylation of sulfamides.
Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Name: Morpholine-4-sulfonamide.
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