Reany, Ofer; Blair, Stephanie; Kataky, Ritu; Parker, David published the artcile< Solution complexation behavior of 1,3,5-trioxycyclohexane based ligands and their evaluation as ionophores for Group IA/IIA metal cations>, Category: amides-buliding-blocks, the main research area is metal selectivity cyclohexanetriol solution complexation ligand conformation hydrogen bond.
A new series of cis,cis-cyclohexane-1,3,5-triol derivatives bearing one, two and three carbamoylalkyl substituents is reported. Ring interconversion promoted by intramol. hydrogen bonding is observed for the mono- and di-alkylated derivatives 3 and 4 depending on solvent polarity. 1H NMR parameters obtained have allowed the calculation of the Gibbs free energy change (ΔG 0) for the trioxa-equatorial ↔ trioxa-axial equilibrium, modeling the conformational changes promoted by ion binding. Selectivity coefficients have been assessed electrochem. using fixed interference methods for the detection of biol. relevant IA/IIA metal cations. Ionophore 4 displays a Nernstian response towards the detection of Ca2+ and logKCa,Mpot values are calculated Solution NMR studies confirm the formation of 1:1 complexes for 4 with lithium, while 2:1 complexation is favored with Ca2+. Detailed ES-MS studies performed under controlled conditions revealed similar trends in ion binding.
Perkin 2 published new progress about Alkali metal ions Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Category: amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics