Moukha-Chafiq, Omar; Reynolds, Robert C. published the artcile< Synthesis and General Biological Activity of a Small Adenosine-5'-(Carboxamide and Sulfanilamide) Library>, Safety of 3-Fluorobenzenesulfonamide, the main research area is preparation screening adenosine carboxamide sulfanilamide library; Adenosine peptide analogs; specific or general biological activities.
A small library of fifty-five adenosine peptide analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from 2′,3′-O-isopropylideneadenosine-5′-carboxylic acid . The coupling of amine or sulfanilamide reactants to the free 5′-carboxylic acid moiety of , in automated solution-phase fashion, led after acid-mediated hydrolysis to target compounds in good yields and high purity. No marked anticancer or antimalarial activity was noted on preliminary cellular testing. Initial screening through the MLPCN program, however, indicates that these analogs may show diverse and interesting biol. activities.
Nucleosides, Nucleotides & Nucleic Acids published new progress about Antimalarials. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Safety of 3-Fluorobenzenesulfonamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics