Momoh, T. B.; Hassan, A. O.; Abaniwo, R. M.; Ojade, F. E.; Olorunnado, G. B. published the artcile< Effect of aqueous leaf extract of Uvariaopsis tripetala on hyperglycaemia, weight loss, polydipsia and polyphagia in alloxan- induced diabetic Wistar rats>, Synthetic Route of 94-20-2, the main research area is Uvariopsis leaf antidiabetic hyperglycemia weight loss polydipsia polyphagi diabetes.
Diabetes, a disorder characterized by hyperglycemia is the leading cause of death in developed, developing and underdeveloped nations around the world today. According to World Health Organization (WHO), its incidence is increasing and assuming epidemic proportions. In this chronic study the antidiabetic effect of orally administered aqueous crude leaf extract of the Uvariopsis tripetala was investigated in Alloxan (150mg/kg) induced diabetic albino rats. The results obtained indicated that after administration of the aqueous extract at different dosages (100, 200, 400 mg/kg body weight) for twenty eight (28) days, there was a time and dosedependent significant (P< 0.05) reduction in FBS on days 7, 14, 21 and 28 compared to diabetic control. The body weight of rats in the treatment groups showed no statistically significant (P>0.05) difference on days 7 and 14 compared to diabetic control. However, a dose-dependent significant (P<0.05) increase was produced by the extract when compared to the diabetic control on days 21 and 28. The extract also showed time and dose-dependent significant (P< 0.05) reduction in food and water consumption in weeks 1, 2, 3 and 4 compared to diabetic control. It was concluded that the aqueous extract of U. tripetala exhibited anti-diabetic properties. Hence this plant may serve as a good candidate for alternative and/or complimentary medicine in the management of diabetes. International Journal of Current Research in Chemistry and Pharmaceutical Sciences published new progress about Antidiabetic agents. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Synthetic Route of 94-20-2.
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