Mishra, Ashish A.; Bhanage, Bhalchandra M. published the artcile< Electronic And Steric Effect Favored Selective Synthesis Of Asymmetric (-) N-Aryl Mandelamides>, SDS of cas: 1192620-83-9, the main research area is asym aryl mandelamide preparation enantioselective; aryl benzoyl formamide asym transfer hydrogenation ruthenium catalyst.
This work reports selective synthesis of asym. (-) α-Hydroxyl Amides like N-aryl mandelamides (S)-4-RC6H4NHC(O)CH(OH)R1 [R = H, Me; R1 = Ph, 2-fluorophenyl, 2,4,6-tris(propan-2-yl)phenyl, etc.] via asym. transfer hydrogenation (ATH) of α-keto Amides like N-aryl benzoyl formamides 4-RC6H4NH(C(O))2R1 using Ru-Tethered TsDPEN catalyst I. The electronic and steric effect at ortho position leading to high enantioselectivity for ATH of carbonyl, sandwiched between two sp2 carbon is studied. A wide range of mono and di ortho substituted α-hydroxyl amide is synthesized using this protocol with good enantioselectivity.
ChemistrySelect published new progress about Amides, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, SDS of cas: 1192620-83-9.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics