Reference of N,2-Dihydroxybenzamide《Bimodal transcranial direct current stimulation reduces alcohol consumption and induces long-term neurochemical changes in rats with neuropathic pain》 was published in 2021. The authors were Santos, Daniela Silva;Medeiros, Liciane Fernandes;Stein, Dirson Joao;De Macedo, Isabel Cristina;Da Silva Rios, Diego Evandro;De Oliveira, Carla;Toledo, Roberta Stroher;Fregni, Felipe;Caumo, Wolnei;Torres, Iraci L. S., and the article was included in《Neuroscience Letters》. The author mentioned the following in the article:
This study aimed to evaluate the effects of repeated bimodal transcranial d.c. stimulation (tDCS) on alc. consumption and immunohistol. and neurochem. parameters in nerve-injured rats. Forty-eight adult male Wistar rats were distributed into six groups: control, neuropathic pain (NP) + sham-tDCS, NP + alc. + sham-tDCS, alc. + sham-tDCS, alc. + tDCS, and NP + alc. + tDCS. NP is induced by chronic sciatic nerve constriction (CCI). The rats were exposed to a 10% alc. solution by voluntary consumption for 14 days. From the 16th day after surgery, bimodal tDCS was applied for 20 min/day for 8 days. Brain structures were collected to evaluate the number of neuropeptide Y (NPY)-pos. neurons, neurites, and argyrophilic grains by immunohistochem., and brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), interleukin (IL)-6, and IL-10 by ELISA. Nerve-injured rats showed a progressive increase in alc. consumption compared to the non-injured rats. In addition, there was a reduction in voluntary alc. consumption over time induced by tDCS. Alc. exposure, chronic pain, and tDCS treatment modulated the central NPY immunoreactivity. tDCS increased the cerebellar levels of IL-6 and IL-10, and CCI and/or tDCS reduced striatal BDNF levels. The current data suggest that tDCS could be a promising non-pharmacol. adjuvant to treat patients with chronic pain who use alc. to relieve their symptoms.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.
N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Reference of N,2-Dihydroxybenzamide
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