Guo, Yongbiao; Gao, Zhenhua; Li, Junchen; Bi, Xiaojing; Shi, Enxue; Xiao, Junhua published the artcile< Practical catalytic enantioselective synthesis of 2,3-dihydroquin-azolinones by chiral bronsted acid catalysis>, Name: 2-Amino-4-bromobenzamide, the main research area is dihydroquinazolinone preparation enantioselective.
Herein, The highly efficient and practical synthesis of 2,3-dihydroquinazolinones I [R1 = n-Pr, cyclohexyl, Ph, etc.; R2 = H, Me, allyl; R3 = H, Me; R4 = H, 6-Me, 7-Cl, etc.; X = O, S] directly from diverse aldehydes with excellent yields and enantioselectivity was reported. Particularly, this protocol afforded better enantiocontrol for aliphatic aldehydes (up to 99% yield, 97% ee), which always gave unsatisfactory results in the previous studies. Moreover, this catalytic system showed wide tolerance to different functional groups such as alkenyl, nitro and halogens. Most importantly, its practicability was well elucidated via the gram-scale synthesis of different types of products at 0.1 mol% catalyst loading and the simplified work-up procedure. To better understand the reaction pathway and origin of the enantioselectivity, DFT calculations were also performed.
Organic & Biomolecular Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Name: 2-Amino-4-bromobenzamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics