Goodman, Patricia A.; Niehoff, Lisa B.; Uckun, Fatih M. published the artcile< Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells>, Synthetic Route of 5004-88-6, the main research area is gamma irradiation cjun lymphocyte tyrosine kinase.
Exposure of B-lineage lymphoid cells to ionizing radiation induces an elevation of c-jun proto-oncogene mRNA levels. This signal is abrogated by protein-tyrosine kinase (PTK) inhibitors, indicating that activation of an as yet unidentified PTK is mandatory for radiation-induced c-jun expression. Here, we provide exptl. evidence that the cytoplasmic tyrosine kinases BTK, SYK, and LYN are not required for this signal. Lymphoma B-cells rendered deficient for LYN, SYK, or both by targeted gene disruption showed increased c-jun expression levels after radiation exposure, but the magnitude of the stimulation was lower than in wild-type cells. Thus, these PTKs may participate in the generation of an optimal signal. Notably, an inhibitor of JAK-3 (Janus family kinase-3) abrogated radiation-induced c-jun activation, prompting the hypothesis that a chicken homolog of JAK-3 may play a key role in initiation of the radiation-induced c-jun signal in B-lineage lymphoid cells.
Journal of Biological Chemistry published new progress about Animal gene, c-jun Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Synthetic Route of 5004-88-6.
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