Prasathkumar, Murugan;Raja, Kannan;Vasanth, Krishnan;Khusro, Ameer;Sadhasivam, Subramaniam;Sahibzada, Muhammad Umar Khayam;Gawwad, Mohamed Ragab Abdel;Al Farraj, Dunia A.;Elshikh, Mohamed S. published 《Phytochemical screening and in vitro antibacterial, antioxidant, anti-inflammatory, anti-diabetic, and wound healing attributes of Senna auriculata (L.) Roxb. leaves》 in 2021. The article was appeared in 《Arabian Journal of Chemistry》. They have made some progress in their research.Recommanded Product: 112-84-5 The article mentions the following:
This study was aimed to determine total phytochem. components as well as in vitro antibacterial, antioxidant, anti-inflammatory, anti-diabetic, and wound healing attributes of Senna auriculata (L.) Roxb. leaves extract Among different solvent extracts tested, methanolic extract revealed maximum alkaloid, flavonoids, phenolic, and tannin contents of 90.41 ± 0.15 mg atropine equivalent/g, 156.64 ± 0.97 mg quercetin equivalent/g, 155.44 ± 1.65 mg gallic acid equivalent/g, and 121.31 ± 2.34 mg gallic acid equivalent/g of extract, resp. Antibacterial activity of methanolic extract was determined against indicator pathogens using agar well diffusion assay which exhibited potential activity against Bacillus subtilis. Antioxidant, anti-inflammatory, anti-diabetic, and wound healing attributes of methanolic extract were analyzed using standard methodologies. The extract exhibited potential antioxidant traits by scavenging ABTS (IC50 value – 224.2 μg/mL) and DPPH (IC50 value – 76.24 μg/mL) in a concentration dependent manner. Further, the extract demonstrated significant anti-inflammatory activities at varied doses with IC50 value of 55.7 μg/mL. The methanolic extract exhibited promising rates of α-amylase and α-glucosidase inhibition with IC50 values of 49.45 and 38.72 μg/mL, resp. Further, the extract showed no toxicity on L929 mouse fibroblast cell lines (99.66 ± 0.14% cell viability). Most importantly, the treatment of cell monolayer of L929 mouse fibroblast cell lines with methanolic extract showed high rate (100%) of wound healing trait. GC-MS anal. of methanolic extract revealed the presence of Mome inositol, 13-Docosenamide, (Z)-, Cycloheptasiloxane, tetradecamethyl-, and Octadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester as predominant compounds In conclusion, the biol. properties of S. auriculata leaves suggested its vast role as ideal antibacterial, antioxidant, anti-inflammatory, anti-diabetic, and wound healing agents in future. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .
cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Recommanded Product: 112-84-5 It is commonly used as a slip additive in the plastic manufacturing industry.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics