Callingham, Michael; Blum, Francesca; Pave, Gregoire published the artcile< One-Step Synthesis of 2-Chloropyrimidin-4-ol Derivatives: An Unusual Reactivity of Thiophosgene>, HPLC of Formula: 5004-88-6, the main research area is quinazoline oxazinone fused pyrimidine bicycle preparation; aminoamide reaction thiophosgene.
A novel, high-yielding, one-step synthesis of 2-chloroquinazolin-4-ols and analogous bicycles from 2-aminoamides using thiophosgene is described. The scope of the reaction includes aminothioamides, amino acids, and fused heterocycle derivatives, furnishing quinazolines, oxazinones, and substituted fused pyrimidine bicycles, resp. On the basis of observed results with substituted analogs, a mechanism for this transformation is thought to occur via an isothiocyanate intermediate followed by an unexpected chemoselective reaction of thiophosgene on the thiol intermediate.
Organic Letters published new progress about Amino amides Role: RCT (Reactant), RACT (Reactant or Reagent). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, HPLC of Formula: 5004-88-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics