Month: October 2022

On September 30, 2021, Ogurtsov, Vladimir A.; Rakitin, Oleg A. published an article.Category: amides-buliding-blocks The title of the article was (2,3-Dihydro-1H-indol-5-ylmethyl)amine. And the article contained the following:

New (2,3-dihydro-1H-indol-5-ylmethyl)amine was synthesized from 2-((1-acetylindolin-5-yl)methyl)isoindoline-1,3-dione by simultaneous deprotection of phthalimide and acetyl groups. The structure of the newly synthesized compounds was established by elemental anal., high resolution mass-spectrometry, 1H, 13C NMR and IR spectroscopy and mass-spectrometry. The resulting compound is a convenient intermediate for various disubstituted 1-(indolin-5-yl)methanamines, which may be of interest as substances with useful pharmacol. properties. The experimental process involved the reaction of Azepan-2-one(cas: 105-60-2).Category: amides-buliding-blocks

The Article related to dihydroindolyl methyl amine preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zamani, Parisa; Khosropour, Ahmad R. published an article in 2016, the title of the article was A combination of natural deep eutectic solvents and microflow technology: a sustainable innovation for the tandem synthesis of 3-aminohexahydrocoumarins.Name: 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

We describe herein the first, straightforward, green, and metal-free tandem continuous flow pseudo-four component reaction to form 3-aminohexahydrocoumarins using choline chloride-urea as a natural deep eutectic solvent. This technol. exhibited superior yields relative to the batch reactions. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Name: 2-(4-Methylbenzamido)acetic acid

The Article related to eutectic microflow technol aminohexahydrocoumarin, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Shaifali; Sheetal; Bains, Rohit; Kumar, Ajay; Ram, Shankar; Das, Pralay published an article in 2020, the title of the article was Supported palladium catalyzed aminocarbonylation of aryl iodides employing bench-stable CO and NH3 surrogates.Synthetic Route of 102-07-8 And the article contains the following content:

A simple, efficient and phosphine free protocol for carbonylative synthesis of primary aromatic amides under polystyrene supported palladium (Pd@PS) nanoparticle (NP) catalyzed conditions has been demonstrated. Herein, instead of using two toxic and difficult to handle gases simultaneously, we have employed the solid, economical, bench stable oxalic acid as the CO source and ammonium carbamate as the NH3 source in a single pot reaction. For the first time, we have applied two non-gaseous surrogates simultaneously under heterogeneous catalyst (Pd@PS) conditions for the synthesis of primary amides using an easy to handle double-vial (DV) system. The developed strategy showed a good functional group tolerance towards a wide range of aryl iodides and afforded primary aromatic amides in good yields. The Pd@PS catalyst was easy to sep. and can be recycled up to four consecutive runs with small loss in catalytic activity. We have successfully extended the scope of the methodol. to the synthesis of isoindole-1,3-diones from 1,2-dihalobenzene, 2-halobenzoates and 2-halobenzoic acid following double and single carbonylative cyclization approaches. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Synthetic Route of 102-07-8

The Article related to aryl iodide aminocarbonylation palladium polystyrene, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Synthetic Route of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Darvishi, Atefeh; Bakhshi, Hadi; Heydari, Akbar published an article in 2022, the title of the article was Innovative application of magnetically modified bovine horn as a natural keratin resource in the role of value-added organocatalyst.Application In Synthesis of 1,3-Diphenylurea And the article contains the following content:

This study presents the conversion of bovine horn powder (BHP) as an available and low-cost waste material to a value-added highly recyclable catalyst. This green catalyst was prepared through the immobilization of BHP, as a natural keratin resource, on the magnetic Fe3O4 nanoparticles. The successful preparation of the catalyst was fully investigated using Fourier transform IR, X-ray diffraction, and energy-dispersive X-ray spectroscopies as well as field emission SEM, vibrating sample magnetometry, and thermogravimetry. The catalytic efficiency of the prepared magnetic organocatalyst was evaluated in the synthesis of a large series of amide derivatives through the solvent-free transamidation reaction of different amides and amines with yields of 75-96%. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea

The Article related to magnetically modified bovine horn natural keratin organocatalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Application In Synthesis of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 2014, Xuan, Yining; Luo, Yan published an article.COA of Formula: C15H15F3N2O2S The title of the article was Synthesis of bifunctional sulfonamides and study on the catalytic asymmetric aldol reaction. And the article contained the following:

A series of monosulfonamide were synthesized from chiral diamines and were used as the catalysts for asym. aldol reaction between acetone and p-nitrobenzaldehyde. The structure effects of the diamines and the sulfonyl groups were investigated. The effect of additive was also studied. Among all the screened catalysts, the monosulfonamide derived from (1S,2S)-1, 2-diphenylethane-1,2-diamine was identified as the best catalyst for the reaction. In the presence of the catalyst and benzoic acid, the reaction was achieved with moderate yield and enantioselectivity. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).COA of Formula: C15H15F3N2O2S

The Article related to bifunctional sulfonamide chiral diamine catalytic asym aldol reaction, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.COA of Formula: C15H15F3N2O2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2021, Simonov, A. Yu.; Panov, A. A.; Trenin, A. S.; Korolev, A. M.; Lavrenov, S. N. published an article.Product Details of 79-07-2 The title of the article was Optimization of the Synthesis of New Antibacterial Compounds with Tris(1-Alkylindol-3-yl)Methylium Fragments. And the article contained the following:

A new optimal synthetic scheme for new antibacterial compounds I (R = H, Me) combining tris-(1-alkyindol-3-yl)methylium and 3-(indol-1-yl)maleimide in their structures was developed. The proposed method provided a significant increase in the product yield, reduced the labor intensiveness and number of steps, and used readily accessible starting reagents. A good yield was achieved for 3-(formylindol-1-yl)-4-chloromaleimide, a universal precursor enabling two-step syntheses of target tri(indolyl)methanes II (R1 = H, NH2, NMe2) and production of an extensive library of analogous potentially active compounds from other 1-alkylindoles and various amines and thiols. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to aminomaleimido trisindolylmethylium chloride preparation antibacterial, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fiorio, Jhonatan L.; Rossi, Liane M. published an article in 2021, the title of the article was Clean protocol for deoxygenation of epoxides to alkenes via catalytic hydrogenation using gold.Electric Literature of 5455-98-1 And the article contains the following content:

The epoxidation of olefin as a strategy to protect carbon-carbon double bonds is a well-known procedure in organic synthesis, however the reverse reaction, deprotection/deoxygenation of epoxides is much less developed, despite its potential utility for the synthesis of substituted olefins. Here, we disclose a clean protocol for the selective deprotection of epoxides, by combining com. available organophosphorus ligands and gold nanoparticles (Au NP). Besides being successfully applied in the deoxygenation of epoxides, the discovered catalytic system also enables the selective reduction N-oxides and sulfoxides using mol. hydrogen as reductant. The Au NP catalyst combined with triethylphosphite P(OEt)3 is remarkably more reactive than solely Au NPs. The method is not only a complementary Au-catalyzed reductive reaction under mild conditions, but also an effective procedure for selective reductions of a wide range of valuable mols. that would be either synthetically inconvenient or even difficult to access by alternative synthetic protocols or by using classical transition metal catalysts. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1

The Article related to clean protocol deoxygenation epoxide alkene catalytic hydrogenation gold, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Electric Literature of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2020, Serrao, Reena Saritha; Shamshuddin, S. Z. Mohamed; Kumar, T. E. Mohan; Mandara, H. M. published an article.HPLC of Formula: 102-07-8 The title of the article was Catalytic microwave synthesis of biphenyl urea over mesoporous ZrO2-Al2O3. And the article contained the following:

Solid acids such as ZrO2, Al2O3 and ZrO2-Al2O3 were prepared and analyzed for their physico-chem. properties like surface acidity and acid site distribution by NH3-TPD, crystalline nature by powder XRD, functionality by FT-IR, morphol. by TEM and elemental anal. by ICP-OES methods. These solid acids were used as catalysts in the solvent-free synthesis of biphenyl urea using microwave irradiation technique starting from aniline and di-Me carbonate. Surface acidity and the phase of the solid acid were found to have a significant role in the synthesis of biphenyl urea. Up to (98%) yield of biphenyl urea with 100% selectivity was obtained in just 12 min. The activity of ZrO2-Al2O3 was compared with Mo(VI)/ZrO2 which is a solid super acid. For comparison, the reactions were also carried out by using conventional heating method. Kinetic studies were carried out to determine energy of activation of the solid acids. These solid acid catalysts were found to be reactivable and reusable when used for up to six reaction cycles. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).HPLC of Formula: 102-07-8

The Article related to zirconium dioxide aluminum trioxide catalyst microwave synthesis biphenyl urea, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.HPLC of Formula: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2022, Vala, Anand; Parmar, Deepa; Rayani, Rahul; Kusurkar, Rakesh; Guduru, Ramakrishna; Kaneriya, Uttam; Gondaliya, Uday; Parmar, Nirali; Soni, Jigar Y. published an article.Synthetic Route of 102-07-8 The title of the article was 1,4,2-Dioxazol-5-ones as Isocyanate Equivalents: Chemoselective Non-Metal-Catalyzed Carboxamidation of Indoles. And the article contained the following:

1,4,2-Dioxazol-5-ones are known to undergo decarboxylation under thermal conditions followed by Lossen’s rearrangement to give isocyanates. Described herein is the in situ trapping of the isocyanates by indoles to give indole-3-carboxamides in good to excellent yields. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Synthetic Route of 102-07-8

The Article related to indole carboxamide preparation chemoselective, dioxazolone indole carboxamidation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 25, 2021, Dahnum, Deliana; Dang, Huyen Tran; Tran, Ngoc Tuan; Ha, Jeong-Myeong; Lee, Hyunjoo published an article.Electric Literature of 102-07-8 The title of the article was One-pot synthesis of 3D-ZIF-7 supported on 2D-Zn-Benzimidazole-Acetate and its catalytic activity in the methoxycarbonylation of aniline with dimethyl carbonate. And the article contained the following:

For the first time, three-dimensional Zeolitic Imidazole Framework (3D) ZIF-7 (Zn(BeIM)2, BeIM = benzimidazole) supported on two-dimensional (2D) Zn(BeIM)OAc (Zinc-Benzimidazole-Acetate) was synthesized by reacting Zn(OAc)2 and benzimidazole in a one-pot reaction. By modulating the amount of diethylamine during the reaction, the ZIF-7/Zn(BeIM)OAc with a 1 to 1 molar ratio was obtained when the reactant molar ratio of Zn(OAc)2 and benzimidazole was 1 to 1.5. It was found that 3D-ZIF-7 was synthesized first and then transformed into 2D-Zn(BeIM)OAc by the reaction with remaining Zn(OAc)2. The synthesized ZIF-7 (Zn(BeIM)2) supported on Zn(BeIM)OAc (1/1) showed enhanced catalytic performance in the methoxycarbonylation of aniline with di-Me carbonate. The yield of Me N-Ph carbamate reached 92.0% in 2 h at 190°C, which was higher than yields obtained using the single component catalysts ZIF-7 (69.9%) and Zn(BeIM)OAc (35.4%). Furthermore, this catalyst was successfully reused four times, maintaining an MPC yield of 92.0%-95.8%. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to zinc benzimidazole acetate aniline dimethyl carbonate methoxycarbonylation catalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics