Month: September 2022

Zhang, Jing;Qian, Xing-Kai;Song, Pei-Fang;Li, Xiao-Dong;Wang, An-Qi;Huo, Hong;Yao, Jing-Chun;Zhang, Gui-Min;Zou, Li-Wei published 《A high-throughput screening assay for dipeptidyl peptidase-IV inhibitors using human plasma》 in 2021. The article was appeared in 《Analytical Methods》. They have made some progress in their research.HPLC of Formula: 2444-46-4 The article mentions the following:

Dipeptidyl peptidase-IV (DPP-IV) plays a critical role in glucose metabolism and has become an important target for type 2 diabetes mellitus. We previously reported a two-photon fluorescent probe glycyl-prolyl-N-butyl-4-amino-1,8-naphthalimide (GP-BAN) for DPP-IV detection with high specificity and sensitivity. In this study, a high-throughput screening (HTS) method for DPP-IV inhibitors using human plasma as the enzyme source was established and optimized. Further investigations demonstrate that the IC₅₀ value of sitagliptin (listed as the DPP-IV inhibitor) determined with human recombinant DPP-IV (36.22 nM) is very similar to that in human plasma (39.18 nM), and sitagliptin acts as a competitive inhibitor against human plasma DPP-IV-mediated GP-BAN hydrolysis. These results indicate that expensive human recombinant DPP-IV can be replaced by human plasma in this GP-BAN-based assay. On this basis, GP-AMC (com. probe) was used as a comparison to verify this method, and the catalytic efficacy (Vmax/Km) for GP-AMC (0.09 min^-1) hydrolysis in human plasma is lower than that for GP-BAN (0.21 min^-1). Further anal. of inhibition kinetics (sitagliptin) and mol. docking (GP-BAN and GP-AMC) showed that GP-BAN has better specificity and affinity for enzymes than GP-AMC. Finally, the optimized method was used for the HTS of DPP-IV inhibitors in 69 natural alkaloids.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.HPLC of Formula: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of cis-13-Docosenamide《Anti-inflammatory and anti-asthmatic effects of TMDCT decoction in eosinophilic asthma through Treg/ Th17 balance》 was published in 2022. The authors were Zhou, Yumei;Zhao, Haihong;Wang, Tieshan;Zhao, Xiaoshan;Wang, Ji;Wang, Qi, and the article was included in《Frontiers in Pharmacology》. The author mentioned the following in the article:

Tuo-Min-Ding-Chuan decoction (TMDCT) is a Traditional Chinese Medicine (TCM) formula consisting of twelve herbs that can relieve the symptoms and treat allergic asthma. Yet, the underlying mechanism of action is still unclear. In this study, we investigated the effect of TMDCT in regulating Treg/Th17 cells immune balance and explored potential metabolic and gut biomarkers associated with Treg and Th17 cells in eosinophilic asthma mice treated by TMDCT. We found that TMDCT increases Treg cells percentage and decreases Th17 cells percentage in the ovalbumin (OVA) -induced eosinophilic asthma mice model. Furthermore, Imidazoleacetic acid, DL-glutamine, L-pyroglutamic acid, 2-deoxy-D-glucose were preliminary identified as biomarkers in plasma metabolites treated by TMDCT, meanwhile genus Desulfovibrio, genus Butyricimonas and genus Prevotella 9 were preliminary identified as gut microbiota biomarkers after TMDCT treatment. These results provide an exptl. foundation for the treatment of allergic asthma with Chinese herbal compoundscis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Safety of cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Zi;Lu, Dongdong;Xie, Hangqing;Yang, Xiaolei;Li, Yang;Bao, Chenhao;Lei, Lei;Xu, Shiqing published 《Triplet Exciton Enhanced Radioluminescence of Ga³⁺/Tb³⁺ Metallacrown Scintillators for X-Ray Detection》. The research results were published in《Advanced Optical Materials》 in 2022.Recommanded Product: N,2-Dihydroxybenzamide The article conveys some information:

The increasing demand for radiation detection in many applications has led to demanding requirements for scintillators. Realizing low-dose, pollution-free, and reliable X-ray detection has become a key tech. challenge. Here, a triplet-enhanced lanthanide radioluminescence (RL) material Ga³⁺/Tb³⁺ metallacrowns (Tb-1) is reported. This Tb-1 crystal emits bright green luminescence under UV light or X-ray excitation, and the emission intensity is 286 and 242 times that of Tb³⁺ in inorganic salt, resp. Tb-1 crystal is further passivated by trioctylphosphine oxide (TOPO), and the enhanced RL intensity is equivalent to that of com. Tl-doped cesium iodide scintillator. In addition, RL of Tb-1-TOPO has an extremely narrow full width at half maximum and an excellent linear response to the X-ray dose rate. The detection limit is calculated to be 0.146μGy s^-1, which is 38 times lower than typical medical imaging doses. Triplet-enhanced lanthanide RL provides new ideas for replacing scintillators that require high temperature synthesis processes such as inorganic phosphors and ceramics, and provides a new alternative scintillator material for flexible X-ray monitoring, bioimaging, radiotherapy, and other applications. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Recommanded Product: N,2-DihydroxybenzamideIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 6-AminonicotinamideIn 2016, Arts, Rob J. W.;Novakovic, Boris;ter Horst, Rob;Carvalho, Agostinho;Bekkering, Siroon;Lachmandas, Ekta;Rodrigues, Fernando;Silvestre, Ricardo;Cheng, Shih-Chin;Wang, Shuang-Yin;Habibi, Ehsan;Goncalves, Luis G.;Mesquita, Ines;Cunha, Cristina;van Laarhoven, Arjan;van de Veerdonk, Frank L.;Williams, David L.;van der Meer, Jos W. M.;Logie, Colin;O’Neill, Luke A.;Dinarello, Charles A.;Riksen, Niels P.;van Crevel, Reinout;Clish, Clary;Notebaart, Richard A.;Joosten, Leo A. B.;Stunnenberg, Hendrik G.;Xavier, Ramnik J.;Netea, Mihai G. published 《Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity》. 《Cell Metabolism》published the findings. The article contains the following contents:

Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by β-glucan in monocytes. Accumulation of fumarate, due to glutamine replenishment of the TCA cycle, integrates immune and metabolic circuits to induce monocyte epigenetic reprogramming by inhibiting KDM5 histone demethylases. Furthermore, fumarate itself induced an epigenetic program similar to β-glucan-induced trained immunity. In line with this, inhibition of glutaminolysis and cholesterol synthesis in mice reduced the induction of trained immunity by β-glucan. Identification of the metabolic pathways leading to induction of trained immunity contributes to our understanding of innate immune memory and opens new therapeutic avenues.6-Aminonicotinamide (cas: 329-89-5) were involved in the experimental procedure.

6-Aminonicotinamide (cas:329-89-5)Recommanded Product: 6-Aminonicotinamide is an aminopyridine, which is a specific pentose inhibitor and thus inhibits the NADP production.It can be used as a reactant for the synthesis of 6-substituted imidazo[1,2-a]pyridines with potential application as chemotherapeutic drugs.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Wenjuan;Liu, Dianwen;Feng, Qicheng published 《Enhancement of salicylhydroxamic acid adsorption by Pb(II) modified hemimorphite surfaces and its effect on floatability》 in 2020. The article was appeared in 《Minerals Engineering》. They have made some progress in their research.Application In Synthesis of N,2-Dihydroxybenzamide The article mentions the following:

Hemimorphite is an important zinc oxide mineral, but only a few studies have been conducted on the enhanced flotation recovery of hemimorphite with salicylhydroxamic acid (SHA) as the collector. In this study, the effect of Pb(II) on SHA adsorption on the hemimorphite surface with regard to its floatability was systematically studied. XPS anal. showed that the Pb species could interact with O sites on the hemimorphite surface, thus forming -Zn-O-Pb and -Si-O-Pb complexes on the mineral surface and exhibiting strong reactivity toward SHA. Zeta potential measurements indicated that Pb²⁺ and Pb(OH)⁺ adsorbed onto the hemimorphite surfaces via phys. and chem. adsorption within a pH range that was suitable for the flotation, further enhancing SHA adsorption on the activated mineral surface. Adsorption tests showed that more SHA adsorbed on the Pb-treated hemimorphite surface than on the untreated hemimorphite, and Pb-SHA complexes that were generated in the pulp solution could also adsorb on the surface of hemimorphite. Micro-flotation tests confirmed that the floatability of hemimorphite significantly increased after treatment with Pb(II) ions when SHA was used as the collector. Thus, this paper proposes a promising method of improving the flotation recovery of hemimorphite through via surface modification with Pb(II) ions. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Application In Synthesis of N,2-DihydroxybenzamideIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Huihui;Hao, Shilai;Chen, Zheng;O-Thong, Sompong;Fan, Jiajun;Clark, James;Luo, Gang;Zhang, Shicheng published 《Mesophilic and thermophilic anaerobic digestion of aqueous phase generated from hydrothermal liquefaction of cornstalk: Molecular and metabolic insights》. The research results were published in《Water Research》 in 2020.Recommanded Product: 6-Aminonicotinamide The article conveys some information:

The critical challenge of hydrothermal liquefaction (HTL) for bio-oil production from biomass is the production of large amounts of aqueous products (HTL-AP) with high organic contents. The present study investigated the anaerobic digestion (AD) performances of HTL-AP under both thermophilic and mesophilic conditions, and mol. and metabolic anal. were conducted to provide insights into the different performances. The results showed that thermophilic AD had lower COD removal efficiency compared to mesophilic AD (45.0% vs. 61.6%). Liquid chromatog. coupled with organic carbon detection and organic nitrogen (LC-OCD-OND) anal. showed that both high mol. weight (HMW) and low mol. weight (LMW) compounds were degraded to some extent and more LMW acids (LMWA) and recalcitrant aromatic compounds were degraded in the mesophilic reactor, which was the main reason of higher COD removal efficiency. Ph compounds (e.g. phenol and 2 methoxyphenol), furans and pyrazines were the recalcitrant chems. detected through GC-MS anal. Fourier transform ion cyclone resonance mass spectrometry (FT-ICR-MS) anal. demonstrated the complexity of HTL-AP and the proportions of phenolic or condensed aromatic compounds increased especially in the thermophilic effluents. Metabolites anal. showed that the reasons contributing to the differences of mesophilic and thermophilic AD were not only related to the degradation of organic compounds (e.g. benzoate degradation via CoA ligation) in HTL-AP but also related to the microbial autogenesis (e.g. fatty acid biosynthesis) as well as the environmental information processing. In addition, the enrichment of Mesotoga, responsible for the high degradation efficiency of LMWA, and Pelolinea, involved in the degradation of Ph compounds, were found in mesophilic reactor, which was consistent with higher removal of corresponding organics To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Recommanded Product: 6-Aminonicotinamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme,6-phosphogluconate dehydrogenase, it interferes with glycolysis.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Parkhitko, Andrey A.;Priolo, Carmen;Coloff, Jonathan L.;Yun, Jihye;Wu, Julia J.;Mizumura, Kenji;Xu, Wenping;Malinowska, Izabela A.;Yu, Jane;Kwiatkowski, David J.;Locasale, Jason W.;Asara, John M.;Choi, Augustine M. K.;Finkel, Toren;Henske, Elizabeth P. published 《Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide》. The research results were published in《Molecular Cancer Research》 in 2014.COA of Formula: C6H7N3O The article conveys some information:

The mammalian target of rapamycin complex 1 (mTORC1) is hyperactive in many human cancers and in tuberous sclerosis complex (TSC). Autophagy, a key mTORC1-targeted process, is a critical determinant of metabolic homeostasis. Metabolomic profiling was performed to elucidate the cellular consequences of autophagy dysregulation under conditions of hyperactive mTORC1. It was discovered that TSC2-null cells have distinctive autophagy-dependent pentose phosphate pathway (PPP) alterations. This was accompanied by enhanced glucose uptake and utilization, decreased mitochondrial oxygen consumption, and increased mitochondrial reactive oxygen species (ROS) production Importantly, these findings revealed that the PPP is a key autophagy-dependent compensatory metabolic mechanism. Furthermore, PPP inhibition with 6-aminonicotinamide (6-AN) in combination with autophagy inhibition suppressed proliferation and prompted the activation of NF-κB and CASP1 in TSC2-deficient, but not TSC2-proficient cells. These data demonstrate that TSC2-deficient cells can be therapeutically targeted, without mTORC1 inhibitors, by focusing on their metabolic vulnerabilities. Implications: This study provides proof-of-concept that therapeutic targeting of diseases with hyperactive mTORC1 can be achieved without the application of mTORC1 inhibitors. Mol Cancer Res; 12(1); 48-57. ©2013 AACR. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)COA of Formula: C6H7N3O is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM). 6-Aminonicotinamide also reduces cardiovascular oxidative injury following ischemia/reperfusion.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: cis-13-Docosenamide《Effects of nanocrystallization on surface migration of polypropylene/slip agent composites in accelerated aging》 was published in 2022. The authors were Won, Jong Sung;Lee, Jae Min;Lee, Pil Gyu;Choi, Hyeong Yeol;Kwak, Tae Joon;Lee, Seung Goo, and the article was included in《Journal of Materials Science》. The author mentioned the following in the article:

The accelerated thermal aging of plastics causes the migration of additives onto specimen surfaces. This is commonly called the “blooming” or “whitening” phenomenon and has long been an issue in the automotive applications of thermoplastic composites. Still, there is a lack of scientific reports regarding crystallization behavior to our best knowledge. This study investigates the mechanism and characteristics of slip agent migration onto injection-molded composite surfaces depending on the behavior of nanocrystn. with thermal aging and develops a method to evaluate the correlation between the internal and external crystallization size and migration of the composites. Slip agent migration was investigated by increasing the spherulite size of PP/slip agent composites, as measured by X-ray diffraction anal. at different periods. It was found that as the crystalline area increased, the low mol. weight slip agents present in the amorphous region migrated to the specimen surface owing to the absence of interactions with the polymer. In addition, surface elemental anal., lightness, and roughness confirmed that the slip agents migrated to the surface in accelerated thermal aging conditions. The findings of this work provide a better understanding of the correlation between thermal aging and the migration phenomenon of slip agents on the surfaces of thermoplastic composites.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Recommanded Product: cis-13-Docosenamide It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gubala, Dajana;Fox, Laura J.;Harniman, Robert;Hussain, Hadeel;Robles, Eric;Chen, Meng;Briscoe, Wuge H. published 《Heads or tails: Nanostructure and molecular orientations in organised erucamide surface layers》 in 2021. The article was appeared in 《Journal of Colloid and Interface Science》. They have made some progress in their research.Product Details of 112-84-5 The article mentions the following:

Despite the widespread industrial usage of erucamide as a slip additive to modify polymer surface properties, a controversy appears to have persisted regarding the nanostructure of erucamide surface layers, particularly the mol. orientation at the outermost layer. The erucamide nanostructure and mol. orientation, along with its surface coverage, hydrophobicity, and adhesive response, can be tuned by simply varying the erucamide concentration in the solution from which the spin coated layer is prepared Synchrotron X-ray reflectivity (XRR) allowed a comprehensive characterization of the out-of-plane structural parameters (e.g. mol. packing and thickness) of the erucamide layers prepared via spin coating from nonaqueous solution on silica. Complementary Atomic Force Microscopy (AFM) imaging with high lateral resolution revealed localised in-plane structures. Contact angle measurements provided information on the wettability of erucamide-coated surfaces. Peak Force Quant. Nanomech. Mapping (QNM) allowed a correlation between the erucamide nanostructure with the surface nanomech. properties (i.e. adhesive response). Our results reveal erucamide surface nanostructures on silica as patchy monolayers, isolated circular bilayers/rounded rectangle-like aggregates and overlapping plate-like multilayers as the erucamide concentration in the spin coating solution was varied. In all the cases, XRR and AFM results were consistent with the picture that the erucamide tails were oriented outwards. The QNM adhesion force mapping of all the observed morphologies also supported this mol. orientation at the outermost erucamide monolayer. The wettability study further confirmed this conclusion with the observed increase in the surface hydrophobicity and coverage upon increasing erucamide concentration, with the macroscopic water contact angle θ = 92.9° ± 2.9° at the highest erucamide concentration of 2 wt%.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Product Details of 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hernandez-Esquivel, Alma Alejandra;Castro-Mercado, Elda;Garcia-Pineda, Ernesto published 《Comparative Effects of Azospirillum brasilense Sp245 and Pseudomonas aeruginosa PAO1 Lipopolysaccharides on Wheat Seedling Growth and Peroxidase Activity》 in 2021. The article was appeared in 《Journal of Plant Growth Regulation》. They have made some progress in their research.Electric Literature of C7H7NO3 The article mentions the following:

The effects of lipopolysaccharides (LPS) from Azospirillum brasilense Sp245, a plant growth-promoting rhizobacteria, and Pseudomonas aeruginosa PAO1, a pathogenic bacterium, on plant growth and peroxidase (POD) activity were assessed on wheat seedlings. A. brasilense LPS (100μg/mL) increased total length, and total fresh weight in wheat seedlings 4 days after treatment. P. aeruginosa LPS did not show effect on plant growth. A. brasilense LPS increased root hairs length similar to whole cells, while P. aeruginosa LPS increased root hairs d. and slightly root hairs length. Both LPS increased POD activity and hydrogen peroxide (H2O2) content in root; however, the LPS from the pathogenic bacterium generated higher increments. The peroxidase inhibitor salicylhydroxamic acid (SHAM) inhibited plant growth, which was not recovered by the addition of LPS neither A. brasilense nor P. aeruginosa. POD activity stimulated by LPS was calcium-dependent as confirmed by the addition of the calcium channel blocker LaCl3. The results suggest that plant cells sense differentially LPS from beneficial or pathogenic bacteria and that calcium is needed to respond to the presence of both LPS.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Electric Literature of C7H7NO3

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics