Month: September 2022

S., Nalumpang;T., Poti;K., Akimitsu published 《Effect of salicylhydroxamic acid on mycelial growth and baseline sensitivity to azoxystrobin in Phytophthora infestans causing potato late blight in Thailand》. The research results were published in《International Journal of Agricultural Technology》 in 2021.Recommanded Product: N,2-Dihydroxybenzamide The article conveys some information:

Late blight of potato caused by Phytophthora infestans is proved to be an aggressive pathogen. Azoxystrobin, a broad spectrum quinone outside inhibitor (QoI), has been used in potato cultivation, but not directly recommended to use to control late blight disease. In this study, a suitable method to determine the sensitivity of P. infestans against azoxystrobin and azoxystrobin sensitivity to P. infestans population was recorded in Chiang Rai and Chiang Mai, Thailand. The toxicity of SHAM was proved a nessary of SHAM addition to artificial media for an efficient determination of azoxystrobin sensitivity. Increased of SHAM concentration led increased mycelial inhibition. SHAM at concentration of 5 to 10μg/mL showed less effect to mycelia growth of six representative isolates with means of 5.33 to 12.06% inhibition. Both concentrations of SHAM were applied with azoxystrobin for pre-in vitro sensitivity determination Effective concentration for 50% inhibition (EC50) of azoxystrobin without SHAM was 0.0873μg/mL, and the sensitivity were significantly increased in azoxystrobin amended with SHAM at 5 and 10μg/mL for 55.34 and 70.90%, resp. SHAM at 5μg/mL was used for in vitro sensitivity assay to azoxystrobin. The thirty-six isolates of P. infestans were determined their azoxystrobin sensitivities based on EC₅₀ evaluation. The mean EC50 value of isolate was 0.0531μg/mL and ranged from 0.0005 to 0.4415μg/mL indicating that azoxystrobin was very effective to control the mycelial growth of P. infestans isolated from Chiang Rai and Chiang Mai, Thailand. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Recommanded Product: N,2-Dihydroxybenzamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Luo, Liping;Xu, Longhua;Meng, Jinping;Lu, Jiahui;Wu, Houqin published 《New insights into the mixed anionic/cationic collector adsorption on ilmenite and titanaugite: An in situ ATR-FTIR/2D-COS study》 in 2021. The article was appeared in 《Minerals Engineering》. They have made some progress in their research.HPLC of Formula: 89-73-6 The article mentions the following:

Elucidation of the co-adsorption characteristics of multiple functional groups will help to screen suitable reagents to improve the floatability and comprehensive utilization of valuable minerals. Herein, salicylhydroxamic acid (SHA), an anionic collector with two functional groups, mixed with a cationic collector dodecylamine (DDA) in ilmenite-titanaugite flotation system was in-depth studied mainly using in-situ attenuated total reflectance Fourier transform IR spectroscopy (ATR-FTIR) combined with the two-dimensional correlation spectroscopic anal. (2D-COS) and XPS. The highest flotation separation performance, at pH 8-9, can be achieved using the SHA/DDA complex with a molar ratio of 6:1. Moreover, at. force microscope (AFM) anal. ulteriorly proved the selectivity of the mixed SHA/DDA collector in the ilmenite-titanaugite flotation system. In-situ ATR-FTIR combined with 2D-COS gave the characteristic sequential adsorption and interaction with the functional groups related to SHA/DDA, which was further confirmed in the results of XPS. The preferred adsorption configuration for the adsorption of the mixed collector were drew to explain the flotation separation between ilmenite and titanaugite. It is predictable that the detailed study into the hybrid collectors with multiple functional groups will provide new insights into the design, synthesis and development of more-powerful collectors. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. HPLC of Formula: 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C22H43NO《UHPLC/GC-TOF-MS metabolomics, MTT assay, and molecular docking studies reveal physostigmine as a new anticancer agent from the ethyl acetate and butanol fractions of Kigelia africana (Lam.) Benth. fruit extracts》 was published in 2021. The authors were Fagbohun, Oladapo F.;Olawoye, Babatunde;Ademakinwa, Adedeji N.;Oriyomi, Olumayowa V.;Fagbohun, Oladoyin S.;Fadare, Olatomide A.;Msagati, Titus A. M., and the article was included in《Biomedical Chromatography》. The author mentioned the following in the article:

Kigelia africana plant is widely used as a herbal remedy in preventing the onset and the treatment of cancer-related infections. With the increase in the research interest of the plant, the specific chem. compound or metabolite that confers its anticancer properties has not been adequately investigated. The Et acetate and butanol fractions of the fruit extracts were evaluated by 2-(4,5-dimethylthiazol-2-yl)-3,5-diphenyl-2H-tetrazolium bromide assay against four different cell lines, with the Et acetate fraction having inhibition concentration values of 0.53 and 0.42 μM against Hep G2 and HeLa cells, resp. More than 235 phytoconstituents were profiled using UHPLC-TOF-MS, while more than 15 chem. compounds were identified using GC-MS from the fractions. Mol. docking studies revealed that physostigmine, fluazifop, dexamethasone, sulfisomidine, and desmethylmirtazapine could favorably bind at higher binding energies of -8.3, -8.6, -8.2, and -8.1 kcal/mol, resp., better than camptothecin with a binding energy of -7.9 kcal/mol. The results of this study showed that physostigmine interacted well with topoisomerase IIα and had a high score of pharmacokinetic prediction using absorption, distribution, metabolism, excretion, and toxicity profiles, thereby suggesting that drug design using physostigmine as a base structure could serve as an alternative against the toxic side effects of doxorubicin and camptothecin. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.COA of Formula: C22H43NO

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Martins, Samantha Eslava;Fillmann, Gilberto;Lillicrap, Adam;Thomas, Kevin V. published 《Review: ecotoxicity of organic and organo-metallic antifouling co-biocides and implications for environmental hazard and risk assessments in aquatic ecosystems》 in 2018. The article was appeared in 《Biofouling》. They have made some progress in their research.Related Products of 2444-46-4 The article mentions the following:

A review. Hazard assessments of Irgarol 1051, diuron, 2-(thiocyanomethylthio)benzothiazole (TCMTB), dichloro-octylisothiazolin (DCOIT), chlorothalonil, dichlofluanid, thiram, zinc pyrithione, copper pyrithione, triphenylborane pyridine (TPBP), capsaicin, nonivamide, tralopyril and medetomidine were performed to establish robust environmental quality standards (EQS), based on predicted no effect concentrations (PNECs). Microalgae, zooplankton, fish and amphibians were the most sensitive ecol. groups to all the antifoulants evaluated, especially in the early life stages. No differences were identified between freshwater and seawater species. The use of toxicity tests with non-standard species is encouraged because they increase the datasets, allowing EQS to be derived from probabilistic-based PNECs while reducing uncertainties. The global ban of tributyltin (TBT) has been heralded as a major environmental success; however, substitute antifoulants may also pose risks to aquatic ecosystems. Environmental risk assessments (ERAs) have driven decision-makings for regulating antifouling products, but in many countries there is still a lack of regulation of antifouling biocides which should be addressed. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Related Products of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Travis, Jordan R.;Van Trieste, Gerard P. III;Zeller, Matthias;Zaleski, Curtis M. published 《Crystal structures of two dysprosium-aluminium-sodium [3.3.1] metallacryptates that form two-dimensional sheets》 in 2020. The article was appeared in 《Acta Crystallographica, Section E: Crystallographic Communications》. They have made some progress in their research.Category: amides-buliding-blocks The article mentions the following:

The two [3.3.1] metallacryptate complexes, namely, poly[[μ3-acetato-hexakis(μ-N,N-dimethylformamide)bis(N,N-dimethylformamide)bis[salicylhydroximato(2-)]heptakis[salicylhydroximato(3-)]hexaaluminium(III)dysprosium(III)pentasodium(I)] N,N-dimethylformamide tetrasolvate monohydrate], [DyAl6Na5(OAc)(Hshi)2(shi)7(DMF)8]·4DMF·H2O or {[DyAl6Na5(C7H5NO3)2(C7H4NO3)7(C2H3O2)(C3H7NO)8]·4C3H7NO·H2O}n, 1, and poly[[di-μ4-acetato-nonakis(μ-N,N-dimethylformamide)octakis(N,N-dimethylformamide)tetrakis[salicylhydroximato(2-)]tetradecakis[salicylhydroximato(3-)]dodecaaluminium(III)didysprosium(III)decasodium(I)] N,N-dimethylformamide 6.335-solvate], [DyAl6Na5(OAc)(Hshi)2(shi)7(DMF)8.5]2·6.335DMF or {[Dy2Al12Na10(C7H5NO3)4(C7H4NO3)14(C2H3O2)2(C3H7NO)17]·6.335C3H7NO}n, 2, where shi3- is salicylhydroximate and DMF is N,N-dimethylformamide, both consist of an aluminum-based metallacryptand. In 1 and 2, the metallacryptand encapsulates a dysprosium(III) ion in the central cavity, and the resulting metallacryptates are connected to each other via sodium-DMF linkages to generate a two-dimensional sheet. The metallacryptates of 1 and 2 are the three-dimensional analogs of metallacrowns as the metallacryptates contain a metal-nitrogen-oxygen cyclic repeat unit throughout the complexes. For 1 the building block of the two-dimensional sheet is comprised of only one type of metallacryptate, which is connected to four neighboring metallacryptates via four sodium-DMF linkages. In 2, the building block is a dimeric unit of two metallacryptates. Each dimeric metallacryptate unit is connected to four other dimeric units via six sodium-DMF linkages. The two metallacryptates of each dimeric unit can be considered enantiomers of each other. In both 1 and 2, chirality is imparted to the metallacryptate due to the Λ and Δ propeller configurations of the four octahedral aluminum ions of the metallacryptand shell.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Category: amides-buliding-blocksIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C17H27NO3《Rapid Screening for Exposure to “Non-Target” Pharmaceuticals from Wastewater Effluents by Combining HRMS-Based Suspect Screening and Exposure Modeling》 was published in 2016. The authors were Singer, Heinz P.;Wossner, Annika E.;McArdell, Christa S.;Fenner, Kathrin, and the article was included in《Environmental Science & Technology》. The author mentioned the following in the article:

Active pharmaceutical ingredients (APIs) have raised considerable concern over the past decade due to their widespread detection in water resources and their potential to affect ecosystem health. This triggered many attempts to prioritize the large number of known APIs to target monitoring efforts and testing of fate and effects. However, so far, a comprehensive approach to screen for their presence in surface waters has been missing. We explore a combination of an automated suspect screening approach based on liquid chromatog. coupled to high-resolution mass spectrometry and a model-based prioritization using consumption data, readily predictable fate properties and a generic mass balance model for activated sludge treatment to comprehensively detect APIs with relevant exposure in wastewater treatment plant effluents. The procedure afforded the detection of 27 APIs that had not been covered in our previous target method, which included 119 parent APIs. The newly detected APIs included 7 compounds with a high potential for bioaccumulation and persistence, and also 3 compounds that were suspected to stem from point sources rather than from consumption as medicines. Anal. suspect screening proved to be more selective than model-based prioritization, making it the method of choice for focusing anal. method development or fate and effect testing on those APIs most relevant to the aquatic environment. However, we found that state-of-the-practice exposure modeling used to predict potential high-exposure substances can be a useful complement to point toward oversights and known or suspected detection gaps in the anal. method, most of which were related to insufficient ionization. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Formula: C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jupudi, Srikanth;Jubie, S.;Deepika, N. P.;Dhanabal, S. P. published 《A new pyrimidine alkaloid from the roots of Tadehagi triquetrum (L.) H.Ohashi》 in 2021. The article was appeared in 《Natural Product Research》. They have made some progress in their research.Electric Literature of C22H43NO The article mentions the following:

Tadehagi triquetrum (L.) H. Ohashi, also known as Desmodium triquetrum (Fabaceae) is the most important plant in the herbal remedies. The present study focus on the isolation, in-silico and in-vitro studies of the two alkaloids (5-(4-[(methylcarbamoyl) amino]-2-oxopyrimidin-1(2H)-yl) tetrahydrofuran-2-yl) Me Me carbamate (I) is a novel alkaloid and 13-Docosenamide is a known alkaloid. The chem. structures of compounds have been elucidated based on comprehensive techniques like GCMS, IR and NMR. In order to know the mol. mechanisms for the two compounds, in silico mol. docking study has been performed. Both compounds have shown perfect binding affinity to the enzymes TNFα, IL-4, IL-13 and 5 LOX Enzyme. The compounds also exhibited comparable G-scores and Glide energy values in comparison with the standard dexamethasone. In addition both the compounds have been tested for in vitro antioxidant assay by using ABTS and DPPH method and the results were compared with standard ascorbic acid. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Electric Literature of C22H43NO It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Shengde;Fisher, Joan;Naciff, Jorge;Laufersweiler, Michael;Lester, Cathy;Daston, George;Blackburn, Karen published 《Framework for Identifying Chemicals with Structural Features Associated with the Potential to Act as Developmental or Reproductive Toxicants》. The research results were published in《Chemical Research in Toxicology》 in 2013.Electric Literature of C6H7N3O The article conveys some information:

Developmental and reproductive toxicity (DART) end points are important hazard end points that need to be addressed in the risk assessment of chems. to determine whether or not they are the critical effects in the overall risk assessment. These hazard end points are difficult to predict using current in silico tools because of the diversity of mechanisms of action that elicit DART effects and the potential for narrow windows of vulnerability. DART end points have been projected to consume the majority of animals used for compliance with REACH; thus, addnl. nonanimal predictive tools are urgently needed. This article presents an empirically based decision tree for determining whether or not a chem. has receptor-binding properties and structural features that are consistent with chem. structures known to have toxicity for DART end points. The decision tree is based on a detailed review of 716 chems. (664 pos., 16 neg., and 36 with insufficient data) that have DART end-point data and are grouped into defined receptor binding and chem. domains. When tested against a group of chems. not included in the training set, the decision tree is shown to identify a high percentage of chems. with known DART effects. It is proposed that this decision tree could be used both as a component of a screening system to identify chems. of potential concern and as a component of weight-of-evidence decisions based on structure-activity relationships (SAR) to fill data gaps without generating addnl. test data. In addition, the chem. groupings generated could be used as a starting point for the development of hypotheses for in vitro testing to elucidate mode of action and ultimately in the development of refined SAR principles for DART that incorporate mode of action (adverse outcome pathways). And 6-Aminonicotinamide (cas: 329-89-5) was used in the research process.

6-Aminonicotinamide (cas:329-89-5)Electric Literature of C6H7N3O is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme,6-phosphogluconate dehydrogenase, it interferes with glycolysis.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C6H7N3O《Removal of retained electrospinning solvent prolongs drug release from electrospun PLLA fibers》 was published in 2017. The authors were D’Amato, Anthony R.;Schaub, Nicholas J.;Cardenas, Jesus M.;Fiumara, Andrew S.;Troiano, Paul M.;Fischetti, Andrea;Gilbert, Ryan J., and the article was included in《Polymer》. The author mentioned the following in the article:

A major challenge in developing drug-releasing electrospun nanofibers is obtaining long-term drug release over many weeks with no burst release of drug. Here, we present new methods capable of prolonging the diffusive release of small mol. drugs from electrospun poly-L-lactic acid (PLLA) nanofibers. The methods focus on removal of retained electrospinning solvent through fiber heating, maintaining fibers in a laboratory setting, or a combination of these methods. These post-fabrication methods altered the release characteristics of a model small mol. drug, 6-aminonicotinamide (6AN), from PLLA fibers. Specifically, untreated fibers released 6AN over 9 days, and fibers that underwent a combined treatment of maintenance in a laboratory setting and heating released 6AN over 44 days. The unique and simple method presented here prolongs diffusive release of a small mol. drug from electrospun fibers and has potential to assist in lengthening small mol. drug release from a variety of polymeric nanomaterials. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Formula: C6H7N3O is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chanquia, Santiago N.;Boscaro, Nadia;Alche, Laura;Baldessari, Alicia;Linares, Guadalupe Garcia published 《An Efficient Lipase-Catalyzed Synthesis of Fatty Acid Derivatives of Vanillylamine with Antiherpetic Activity in Acyclovir-Resistant Strains》 in 2017. The article was appeared in 《ChemistrySelect》. They have made some progress in their research.Synthetic Route of C17H27NO3 The article mentions the following:

A series of eleven N-fatty acid derivatives of vanillylamine I was synthesized following an enzymic approach, in excellent yield and a chemoselective way. The excellent results obtained by catalysis of Thermomyces lanuginosus lipase made the procedure very efficient, considering the low amount of enzyme required and its lower price in comparison with other com. lipases. The influence of various reaction parameters in the lipase-catalyzed reactions, such as enzyme source, nucleophile/substrate ratio, enzyme/substrate ratio, solvent and temperature, was studied. To evaluate the influence of the fatty acid chain length and configuration on the reaction rate and yield, HPLC anal. and mol. modeling experiments were performed. The results showed that a chain length between 12-14 carbon atoms favors the activity of the enzyme, while insatn. had no effect on the reaction rate. These facts confirm the exptl. results. In addition, some of the evaluated compounds exhibited antiviral activity against Herpes simplex virus type 1 (HSV-1) KOS strain (TK+) and Field and B2006 strains (TK-) in Vero cells. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Synthetic Route of C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics