Morosanova, Maria A.;Kovalev, Vitaliy A.;Morosanova, Elena I. published 《Silica Xerogel Doped with Iron(III) as Sensor Material for Salicylhydroxamic Acid Determination in Urine》 in 2021. The article was appeared in 《Gels》. They have made some progress in their research.SDS of cas: 89-73-6 The article mentions the following:
Salicylhydroxamic acid (SHA) is used as antimicrobic medicine and its concentration has to be monitored in urine. For the first time, silica xerogels doped with iron(III) have been proposed as sensor materials for SHA determination in biol. samples. Three xerogels with iron(III) content in the range of 0.04-1.74% wt have been synthesized. BET surface area of these xerogels has varied in the range of 696-529 m2/g and total pore volume has varied in the range of 0.92-0.23 cm3/g. Complex formation between immobilized iron(III) and salicylhydroxamic acid has been investigated with solid phase spectrophotometry and IR spectroscopy. Orange-brown iron(III)-SHA complex with 1:1 stoichiometry is formed at pH 1-4 with half-reaction time of 17 min. Silica xerogel doped with 0.33% wt iron(III)) has been used as sensor material for SHA solid phase spectrophotometric determination (LOD 1.4 mg/L (n = 3), anal. range 4-230 mg/L). Proposed sensor material has been applied for SHA determination in biol. samples of synthetic and human urine. The proposed procedusalicylhydroxamic acid re is characterized by a good level of accuracy (recovery values 97-120%) and precision (RSD values 4-9%) and can be recommended for pharmacokinetic-pharmacodynamic studies of hydroxamic acid-based medications.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.
N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. SDS of cas: 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics