De Abrew, K. Nadira;Shan, Yuqing K.;Wang, Xiaohong;Krailler, Jesse M.;Kainkaryam, Raghunandan M.;Lester, Cathy C.;Settivari, Raja S.;LeBaron, Matthew J.;Naciff, Jorge M.;Daston, George P. published 《Use of connectivity mapping to support read across: A deeper dive using data from 186 chemicals, 19 cell lines and 2 case studies》 in 2019. The article was appeared in 《Toxicology》. They have made some progress in their research.Product Details of 329-89-5 The article mentions the following:
The authors previously demonstrated that the Connectivity Map (CMap) (Lamb et al., 2006) concept can be successfully applied to a predictive toxicol. paradigm to generate meaningful MoA-based connections between chems. (De Abrew et al., 2016). Here the authors expand both the chem. and biol. (cell lines) domain for the method and demonstrate two applications, both in the area of read across. In the first application the authors demonstrate CMap’s utility as a tool for testing biol. relevance of source chems. (analogs) during a chem. led read across exercise. In the second application CMap can be used to identify functionally relevant source chems. (analogs) for a structure of interest (SOI)/target chem. with minimal knowledge of chem. structure. Finally, the authors highlight four factors: promiscuity of chem., dose, cell line and timepoint as having significant impact on the output. The authors discuss the biol. relevance of these four factors and incorporate them into a work flow.6-Aminonicotinamide (cas: 329-89-5) were involved in the experimental procedure.
6-Aminonicotinamide (cas:329-89-5)Product Details of 329-89-5 induces apoptosis in tumor cells. It is clinically used in disseminated neoplastic disease. It also acts as 6-phosphogluconate dehydrogenase inhibitor. It aids in the treatment of psoriasis. It is used as cancer chemotherapeutic drug in animals.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics